Results 251 to 260 of about 107,962 (311)

ProteinWeaver: A webtool to visualize ontology-annotated protein networks. [PDF]

open access: yesPLoS One
Anderson O   +5 more
europepmc   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié   +3 more
wiley   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong   +9 more
wiley   +1 more source

A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global alterations related to immune function and identifies potential pathways and cell populations that can be targeted for therapeutic intervention.
Ryan R. White   +9 more
wiley   +1 more source

A multi-tissue single-cell expression atlas in cattle. [PDF]

open access: yesNat Genet
Han B   +37 more
europepmc   +1 more source

Reduced Proteasome Degradation of HSF‐1 Shifts Protein Stress Management With Age in Caenorhabditis elegans

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Ageing C. elegans prioritises chronic protein stress protection over acute stress response by coordinating HSF‐1 activity. Decreased PBS‐7 binding in aged worms reduces HSF‐1 degradation, enhancing its ability to upregulate protective factors against accumulating protein aggregates while simultaneously suppressing its activation under acute heat shock.
Hongwei Wang   +11 more
wiley   +1 more source

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