Results 101 to 110 of about 2,765,689 (216)

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Towards the Simplest Model of Quantum Supremacy: Atomic Boson Sampling in a Box Trap. [PDF]

Entropy (Basel), 2023
Kocharovsky VV, Kocharovsky VV, Shannon WD, Tarasov SV.   +3 more
europepmc   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, Volume 12, Issue 21, June 5, 2025.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang   +10 more
wiley   +1 more source

Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks

JOR SPINE, Volume 8, Issue 2, June 2025.
We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang, Cheng Jiang, Jiong‐Hui Chen, Yong‐Long Chen, Zhen‐Wu Zhang, Zhi‐Chao Yang, Jun Li, Xiao‐Chuan Li   +7 more
wiley   +1 more source

On the adelic Gaussian hypergeometric function [PDF]

arXiv
We define the adelic hypergeometric function of special Gaussian type by means of a tower of hypergeometric curves. This function takes values in an adelic completed group ring and interpolates all the hypergeometric functions of the same type over all finite fields. It specializes at the unit argument to the adelic beta function of Ihara and Anderson.
arxiv  

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen   +6 more
wiley   +1 more source

Comparative transcriptomics reveals different profiles between diflubenzuron‐resistant and ‐susceptible phenotypes of the mosquito Culex pipiens

Pest Management Science, Volume 81, Issue 6, Page 3370-3377, June 2025.
Comparative gene expression analysis between susceptible and diflubenzuron‐resistant individuals of the mosquito Culex pipiens revealed transcriptional changes of multiple genes associated with insecticide detoxification and cuticle synthesis. Abstract Background Chitin‐synthesis inhibitors (CSIs) represent a major tool in vector control. The intensive
Mastrantonio Valentina, Liberati Franco, Castrignanò Tiziana, Lucchesi Valentina, Urbanelli Sandra, Bellini Romeo, Vontas John, Porretta Daniele   +7 more
wiley   +1 more source

Rapid and chemically diverse C transfer from trees to mycorrhizal fruit bodies in the forest

Functional Ecology, Volume 39, Issue 6, Page 1343-1357, June 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ectomycorrhizal fungi (EMF) are common belowground tree symbionts, supplying trees with water and nutrients. In return, large amounts of C assimilated by trees can be allocated into EMF. However, the chemical forms in which the C is transferred from trees to fungi under
Alon Rapaport, Stav Livne‐Luzon, Hagar Fox, Yaara Oppenheimer‐Shaanan, Tamir Klein   +4 more
wiley   +1 more source

Elicitor Specific Mechanisms of Defence Priming in Oak Seedlings Against Powdery Mildew

Plant, Cell &Environment, Volume 48, Issue 6, Page 4455-4474, June 2025.
ABSTRACT Defence priming sensitises plant defences to enable a faster and/or stronger response to subsequent stress. Various chemicals can trigger priming; however, the response remains unexplored in oak. Here, we characterise salicylic acid (SA)‐, jasmonic acid (JA)‐, and β‐aminobutyric acid (BABA)‐induced priming of oak seedlings against the causal ...
Rosa Sanchez‐Lucas, Jack L. Bosanquet, James Henderson, Marco Catoni, Victoria Pastor, Estrella Luna   +5 more
wiley   +1 more source