Results 121 to 130 of about 16,683 (210)

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia‐Reperfusion Injury

open access: yesMedComm, Volume 7, Issue 1, January 2026.
We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Further experiments indicated that cardiogenic Piezo1‐mediated calcium overload exacerbates MIR through the activation of matrix metalloproteinase 2‐ryanodine ...
Zhen Li   +7 more
wiley   +1 more source

Reproducibility of Metabolic Mapping Using 2D Multi‐Slice Short‐TE and GABA‐Edited Spin‐Echo MRSI at 3T in a Single Protocol

open access: yesNMR in Biomedicine, Volume 39, Issue 1, January 2026.
Short‐TE MRSI at 3T enables reproducible metabolic mapping for tNAA, tCr, tCho, mI, and Glx; however, GABA+ mapping with edited MRSI remains challenging due to susceptibility to intermittent subject motion. Although 96% of regions from the short‐TE MRSI met quality control for major metabolites for at least one visit, only 82.5% of voxels of the GABA ...
Helge J. Zöllner   +6 more
wiley   +1 more source

Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development. [PDF]

open access: yesNat Commun, 2023
Zhong S   +15 more
europepmc   +1 more source

Dark diversity in temperate forests of northeastern China: drivers and implications

open access: yesOikos, Volume 2026, Issue 1, January 2026.
Understanding the species composition of a community, including those species present and those absent but potentially able to occur, is vital for assessing biodiversity changes and informing conservation planning. Typically, studies focus on observed taxonomic diversity but ignore undetected species expected to be present based on co‐occurrence ...
Wushuang Li   +7 more
wiley   +1 more source

Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis

open access: yesSmall Science, Volume 6, Issue 1, January 2026.
Current temporomandibular joint osteoarthritis (TMJOA) treatments lack progression control. MicroRNAs (miRNAs) offer therapeutic potential but face delivery hurdles. A novel nanodelivery system is developed using tetrahedral framework nucleic acids functionalized with miR‐143‐3p (tFNAs‐143). Tested in TMJOA models and inflammatory conditions, tFNAs‐143
Wenxiu Yuan   +11 more
wiley   +1 more source

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