Results 231 to 240 of about 549,355 (294)

Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang   +7 more
wiley   +1 more source

Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks. [PDF]

open access: yesFront Pharmacol
Díaz-Santiago E   +7 more
europepmc   +1 more source

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu   +6 more
wiley   +1 more source

Comparative transcriptomics reveals different profiles between diflubenzuron‐resistant and ‐susceptible phenotypes of the mosquito Culex pipiens

open access: yesPest Management Science, Volume 81, Issue 6, Page 3370-3377, June 2025.
Comparative gene expression analysis between susceptible and diflubenzuron‐resistant individuals of the mosquito Culex pipiens revealed transcriptional changes of multiple genes associated with insecticide detoxification and cuticle synthesis. Abstract Background Chitin‐synthesis inhibitors (CSIs) represent a major tool in vector control. The intensive
Mastrantonio Valentina   +7 more
wiley   +1 more source

Differences in Colour Pattern, Behaviour and Gene Expression in the Brain Suggest Divergent Camouflage Strategies in Sympatric Reef Fish Species

open access: yesMolecular Ecology, Volume 34, Issue 11, June 2025.
ABSTRACT Camouflage is a critical survival strategy that helps to evade predation and increase hunting success. Background matching and disruptive colouration are different camouflage strategies that are subject to different selective pressures and can drive divergence in their associated traits such as colour pattern and behaviour.
M. J. Heckwolf   +6 more
wiley   +1 more source

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