Results 241 to 250 of about 38,229 (306)

scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
scCompass integrates and standardizes transcriptomic data from ≈105 million single cells across 13 species, enabling the identification of stable expression genes and organ‐specific expression genes in humans and mice. It provides scalable datasets for AI model training, pretrained model checkpoints, and user‐friendly platforms for data sharing ...
Pengfei Wang   +29 more
wiley   +1 more source

The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth. [PDF]

open access: yesNat Plants
Lyu M   +10 more
europepmc   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng   +10 more
wiley   +1 more source

Massively parallel jumping assay decodes Alu retrotransposition activity. [PDF]

open access: yesNat Commun
Matharu N   +12 more
europepmc   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang   +13 more
wiley   +1 more source

Resurgence of Chern-Simons Theory at the Trivial Flat Connection. [PDF]

open access: yesCommun Math Phys
Garoufalidis S   +3 more
europepmc   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan   +16 more
wiley   +1 more source

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