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Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia. [PDF]
J Atheroscler ThrombXie JJ +9 more
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Hyperhomocysteinemia and cardiovascular diseases
Annales de Biologie Clinique, 2022Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is present in plasma, with normal levels between 5 and 15 μmol/L, a slightly elevated level between 15 to 30 μmol/L, moderate from 30 to 100 μmol/L and a value > 100 μmol/L ...
Guieu, Régis +2 more
openaire +5 more sources
Parkinson’s Disease Risk and Hyperhomocysteinemia: The Possible Link
Cellular and Molecular Neurobiology, 2023 Parkinson’s disease (PD) is one of the most common degenerative brain disorders caused by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and -synuclein accumulation in the SN are hallmarks of the neuropathology of PD.
Hayder M Al-Kuraishy +2 more
exaly +2 more sources
Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?
International Journal of Molecular Sciences, 2021 The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (
Giovanna Mottola +2 more
exaly +2 more sources
Involvements of Hyperhomocysteinemia in Neurological Disorders
Metabolites, 2021 Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite limit.
Marika Cordaro +2 more
exaly +2 more sources
Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease
New England Journal of Medicine, 1991 R. Clarke +6 more
exaly +2 more sources
Thrombosis and Haemostasis, 2022
Thromboembolic manifestations are relativement frequent in patients with intermediate/severe hyperhomocysteinemia (> 30 µmol/L) related to inherited disorders and deficiencies in vitamin B12 and folate.
J. Guéant +4 more
semanticscholar +1 more source
Thromboembolic manifestations are relativement frequent in patients with intermediate/severe hyperhomocysteinemia (> 30 µmol/L) related to inherited disorders and deficiencies in vitamin B12 and folate.
J. Guéant +4 more
semanticscholar +1 more source
Causes of hyperhomocysteinemia and its pathological significance
Archives of Pharmacal Research, 2018Youngjoo Kwon
exaly +2 more sources
Free Radical Biology & Medicine, 2021
Sp1-CSE-H2S pathway plays an important role in homocysteine-metabolism, whose disorder can result in hyperhomocysteinemia. H2S deficiency in hyperhomocysteinemia has been reported, while the underlying mechanism and whether it in turn affects the ...
Chenghua Luo +10 more
semanticscholar +1 more source
Sp1-CSE-H2S pathway plays an important role in homocysteine-metabolism, whose disorder can result in hyperhomocysteinemia. H2S deficiency in hyperhomocysteinemia has been reported, while the underlying mechanism and whether it in turn affects the ...
Chenghua Luo +10 more
semanticscholar +1 more source
Life Science, 2021
AIMS Homocysteine has been linked to neurodegeneration and motor function impairments. In the present study, we evaluate the effect of chronic mild hyperhomocysteinemia on the motor behavior (motor coordination, functional performance, and muscular force)
T. M. dos Santos +5 more
semanticscholar +1 more source
AIMS Homocysteine has been linked to neurodegeneration and motor function impairments. In the present study, we evaluate the effect of chronic mild hyperhomocysteinemia on the motor behavior (motor coordination, functional performance, and muscular force)
T. M. dos Santos +5 more
semanticscholar +1 more source