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Hyperhomocysteinemia, inflammation and autoimmunity
Autoimmunity Reviews, 2007Hyperhomocysteinemia is independently associated with the development of coronary, cerebral and peripheral vascular disease and deep-vein thrombosis in the general population. The evidence that cardiovascular involvement is particularly frequent and advanced in patients affected with several autoimmune diseases (AD), in which hyperhomocysteinemia ...
Lazzerini, P. E. +6 more
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Hyperhomocysteinemia and Venous Thromboembolism
Seminars in Thrombosis and Hemostasis, 2006Homocysteine (Hcy) is a sulfhydryl amino acid derived from the metabolic conversion of methionine, which is dependent on vitamins (folic acid, B12 and B6) as cofactors or cosubstrates. Severe hyperhomocysteinemia (homocystinuria), due to inherited metabolic defects of Hcy metabolism, is associated with very high risk of venous thromboembolism (VTE ...
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Hyperhomocysteinemia and Venous Thrombosis
The International Journal of Lower Extremity Wounds, 2002Deep vein thrombosis (DVT) leads to venous ulcers in later life. Venous ulcers are the majority of chronic lower extremity wounds. Recent evidence suggests that hyperhomocysteinemia is an independent risk factor for venous thrombosis. Other evidence suggests that dietary supplementation with folic acids and vitamins helps to change hyper ...
Paul, Lee, Kailash, Prasad
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Hyperhomocysteinemia, Atherosclerosis and Thrombosis
Thrombosis and Haemostasis, 1999SummaryHigh plasma levels of homocysteine are the results of the interplay between congenital and environmental factors. In the last two decades, a growing amount of interest has focused on mild-to-moderate hyperhomocysteinemia as a risk factor of thromboembolic diseases.
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Hyperhomocysteinemia and Immune Activation
Clinical Chemistry and Laboratory Medicine, 2003Hyperhomocysteinemia is an established risk factor for atherosclerosis, thrombosis and other vascular diseases. Homocysteine auto-oxidation is considered to be crucially involved in the pathogenesis of these diseases. However, the question remains to be elucidated whether vitamin deficiency and homocysteine accumulation are causal for disease ...
Katharina, Schroecksnadel +5 more
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Casopis lekaru ceskych, 1996
Similarly as in other inborn metabolic diseases the cause of hyperhomocysteinaemia are interactions between genetically conditioned changes most frequently due to reduced cystathionine-beta synthase activities and negative factors of the external environment.
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Similarly as in other inborn metabolic diseases the cause of hyperhomocysteinaemia are interactions between genetically conditioned changes most frequently due to reduced cystathionine-beta synthase activities and negative factors of the external environment.
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Hyperhomocysteinemia in organ transplantation
Current Opinion in Urology, 2000An elevated total homocysteine plasma concentration is associated with an increased morbidity and mortality due to cardiovascular disease in the general population, in patients with renal failure and in recipients of kidney or heart transplants. The fasting or post-methionine loading plasma concentration of total homocysteine is elevated in 50-60% of ...
G, Sunder-Plassmann +2 more
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[Hyperhomocysteinemia and vascular disease].
Giornale italiano di cardiologia, 1996Hyperhomocysteinemia, the pathological increase of plasma homocysteine concentrations, is gaining increased attention in atheroscierosis research. Reasons for the wide present interest for this disorder of metabolism are that it may account, in the hereditary heterozygous and the acquired forms, for a still undetermined but possibly very large number ...
Zampolli A, De Caterina R
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