Results 121 to 130 of about 2,331 (162)
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Partialsynthese von Proto‐hypericin und Hypericin aus Penicilliopsin
Chemische Berichte, 1958AbstractEs wird gezeigt, daß die beiden Emodin‐anthron‐(9)‐Reste des Penicilliopsins an den C‐Atomen 8 und 8′ verknüpft sind und Penicilliopsin demnach Diemodin‐anthron‐(9.9′)‐yl‐(8.8′) ist. Penicilliopsin läßt sich durch Chromsäureoxydation in Skyrin und durch Dehydrierung mit Luftsauerstoff in Protohypericin überführen.
Hans Brockmann, Heinrich Eggers
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Hypericin: chemical synthesis and biosynthesis
Chinese Journal of Natural Medicines, 2014Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hypericum belonging to the sections Euhypericum and Campylosporus of Keller's classification. Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of ...
Lin-Fang, Huang +2 more
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Delivery of hypericin for photodynamic applications
Cancer Letters, 2006Early cancer detection is critical in improving disease management outcomes. Cancer diagnosis presents unique difficulties mainly due to its pathological presentation and poor accessibility that could limit the usefulness of conventional white light endoscopy in early cancer detection.
Constance Lay Lay, Saw +3 more
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Hypericin?an inhibitor of proteasome function
Cancer Chemotherapy and Pharmacology, 2005Hypericin is the presumed active moiety within Saint John's wort. Extracts of Saint John's wort are widely used as an effective treatment for depression. Available as "over-the-counter" drugs, they are frequently part of the self-medication of patients undergoing radiation therapy for malignant diseases.
Pajonk, Frank-Gerald B. +2 more
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Potentiation of the Photodynamic Action of Hypericin
Journal of Environmental Pathology, Toxicology and Oncology, 2008Hypericin (HY) is an interesting photosensitizer with dark activity and photodynamic therapy (PDT) effects via p53-independent pathway. In photodynamic diagnosis (PDD) of bladder cancer using HY, very high sensitivity and specificity were reported, in comparison with its counterpart, 5-aminolevulinic acid (5-ALA).
Constance Lay Lay, Saw +2 more
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Exploring Modes of Photokilling by Hypericin
Photochemistry and Photobiology, 2020AbstractEffects of photodynamic therapy (PDT) using the anthraquinone hypericin were explored with OVCAR‐5 cells in vitro. Irradiation resulted in ER > lysosomal photodamage. Paraptosis was identified as a primary death pathway resulting from ER perturbation. This is characterized by an extensive pattern of cytoplasmic vacuole formation.
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Effect of Acetazolamide on Hypericin Photocytotoxicity
Planta Medica, 2002The photodynamic action of hypericin (HYP) in vitro was evaluated using human leukemic HL-60 and lung carcinoma A549 cell lines. After illumination HYP (1 x 10 (-5) M) reduced the proliferation and/or survival of HL-60 and A549 cells vs. controls to almost to 0 % and 29 %, respectively.
Peter, Solár +8 more
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Sensitization of photohemolysis by hypericin and Photofrin®
Journal of Photochemistry and Photobiology B: Biology, 1996Sensitization of post-irradiation (delayed) photohemolysis (DPH) and "during irradiation" (continuous) photohemolysis (CPH) were investigated for sodium hypericin and Photofrin. The photohemolysis rate and relative steepness of the photohemolysis curves were measured for a range of sensitizer concentrations and DPH irradiation times.
M A, al-Akhras, L I, Grossweiner
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Monatshefte für Chemie / Chemical Monthly, 1998
Sulfonation of hypericin leads to its di-, tri-, and tetrasulfonic acid derivatives. The latter is soluble in water up to millimolar solutions. Homoaggregate formation (J-aggregates) was observed only above 5ċ10−4 mol/l. In water solutions, the tetrasulfonic acid hypericin derivative was found to be present as its bay-phenolate with most of the ...
Heinz Falk +3 more
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Sulfonation of hypericin leads to its di-, tri-, and tetrasulfonic acid derivatives. The latter is soluble in water up to millimolar solutions. Homoaggregate formation (J-aggregates) was observed only above 5ċ10−4 mol/l. In water solutions, the tetrasulfonic acid hypericin derivative was found to be present as its bay-phenolate with most of the ...
Heinz Falk +3 more
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Comparative in vitro study of photodynamic activity of hypericin and hypericinates in MCF-7 cells
Journal of Photochemistry and Photobiology B: Biology, 2017In this work we present a comparative in vitro study of photodynamic activity between hypericin (HYP) and some hypericinates (hypericin ionic pair with lysine or N-methylglucamine) in human mammary adenocarcinoma cells (MCF-7). The toxicity and phototoxicity of hypericin and hypericinates were compared, as well as their cellular uptake and localization
Gislaine Patricia, de Andrade +5 more
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