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Journal of Photochemistry and Photobiology B: Biology, 1996
We describe the first local use of hypericin as photosensitizer for photodynamic therapy in a patient with recurrent malignant mesothelioma. Hypericin is a polycyclic quinone, which has been shown to possess in vivo and in vitro antiretroviral and photosensitizing activity; moreover, it is used in depressive disorders.
H, Koren +7 more
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We describe the first local use of hypericin as photosensitizer for photodynamic therapy in a patient with recurrent malignant mesothelioma. Hypericin is a polycyclic quinone, which has been shown to possess in vivo and in vitro antiretroviral and photosensitizing activity; moreover, it is used in depressive disorders.
H, Koren +7 more
exaly +3 more sources
Theoretical study of hypericin
Journal of Photochemistry and Photobiology A: Chemistry, 2005Electronic properties and phototoxic reactions of the hypericin molecule are explored by the use of density functional theory, integral equation formalism polarised continuum model (to include solvent effects) and a time-dependent formalism for the study of singlet and triplet excited states.
Rita C Guedes, Leif A Eriksson
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Hypericin and hypericin-like substances: Analytical problems
1998Abstract Hypericin is a substance derived from Hypericum perforatum L., a plant utilized in the production of extracts used to aromatize alcoholic beverages and soft drinks and limited in food and beverages by the E.E.C. Directives on Flavouring. This paper deals with the H.P.L.C.
F. Tateo +3 more
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Antiviral activities of hypericin
Antiviral Research, 1991Hypericin, a photodynamic plant quinone, readily inactivated murine cytomegalovirus (MCMV), Sindbis virus, and human immunodeficiency virus type 1 (HIV-1), especially on exposure to fluorescent light. Sindbis virus was significantly more sensitive than MCMV.
J B, Hudson +2 more
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Zur Kenntnis des Hypericins und Pseudo‐Hypericins
Chemische Berichte, 1957AbstractBei einer Untersuchung über die Verbreitung von Hypericin bei Hypericum‐Arten wurde ein neuer, dem Hypericin sehr ähnlicher Farbstoff, das Pseudo‐hype‐ricin aufgefunden. Es kann im Ring‐Papierchromatogramm von Hypericin getrennt werden. Einige der untersuchten Hypericum‐Arten bilden Pseudo‐hypericin neben Hypericin, andere nur Pseudo‐hypericin ...
Hans Brockmann, Walter Sanne
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Partialsynthese von Proto‐hypericin und Hypericin aus Penicilliopsin
Chemische Berichte, 1958AbstractEs wird gezeigt, daß die beiden Emodin‐anthron‐(9)‐Reste des Penicilliopsins an den C‐Atomen 8 und 8′ verknüpft sind und Penicilliopsin demnach Diemodin‐anthron‐(9.9′)‐yl‐(8.8′) ist. Penicilliopsin läßt sich durch Chromsäureoxydation in Skyrin und durch Dehydrierung mit Luftsauerstoff in Protohypericin überführen.
Hans Brockmann, Heinrich Eggers
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Properties and Permeability of Hypericin and Brominated Hypericin in Lipid Membranes
Journal of Chemical Theory and Computation, 2009The promising photosensitizing properties of hypericin, a substituted phenanthroperylene quinone naturally found in Saint John's wort, has led to the proposal that it can be utilized in photodynamic therapy. Structurally modified derivatives are at the present time being investigated to generate a more effective hypericin photosensitizer.
Eriksson, Emma S. E. +3 more
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