Results 101 to 110 of about 241,996 (356)

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Monogenic hyperlipidemias.

Acta bio-medica : Atenei Parmensis, 2019
Monogenic hyperlipidemias are a group of inherited disorders characterized by elevated plasma concentrations of lipids and lipoproteins. High plasma concentrations of lipids are the most frequent risk factor for cardiovascular disease. Monogenic hyperlipidemias are a minor cause with respect to multifactorial hyperlipidemias.
Krasi, Geraldo, Bushati, Vilma, Precone, Vincenza, Cortese, Bernardo, Agostini, Francesca, Tezzele, Silvia, Baglivo, Mirko, Cecchin, Stefano, Aquilanti, Barbara, Velluti, Valeria, Matera, Giuseppina, Gagliardi, Lucilla, Miggiano, Giacinto Abele Donato, Bertelli, Matteo   +13 more
openaire   +2 more sources

Impact of diclofenac risk minimization measures addressing cardiovascular risk on analgesic use in musculoskeletal disorders

British Journal of Clinical Pharmacology, EarlyView.
Aims In 2013, risk minimization measures (RMMs) were introduced in Europe to address the increased cardiovascular risk linked to diclofenac. This study aimed to assess the impact of those RMMs on analgesic use. Methods Primary care data from CPRD GOLD (UK) were used.
Tomas Lasys, Yared Santa‐Ana‐Tellez, Satu J. Siiskonen, Daniala L. Weir, Rolf H. H. Groenwold, Helga Gardarsdottir   +5 more
wiley   +1 more source

Factors associated with cardiovascular events after simultaneous liver–kidney transplant from the US Multicenter Simultaneous Liver–Kidney Transplant Consortium

Hepatology Communications, EarlyView., 2022
Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo, Gonzalo Crespo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min Zhang, John Magee, Pranab Barman, Yuval A. Patel, Aaron Schluger, Kara Walters, Scott Biggins, Natalia Filipek, Giuseppe Cullaro, Randi Wong, Jennifer C. Lai, Gabriel J. Perreault, Elizabeth C. Verna, Pratima Sharma, Lisa B. VanWagner   +19 more
wiley   +1 more source

Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state

Journal of Lipid Research, 2000
Potentially atherogenic triglyceride-rich lipoprotein (TRL) remnants can be isolated and quantitated as remnant-like particles (RLP), using an immunoaffinity gel containing specific anti-human apolipoprotein A-I (apoA-I) and apoB-100 monoclonal ...
Caroline Marcoux, Paul N. Hopkins, Tao Wang, Elizabeth Teng Leary, Katsuyuki Nakajima, Jean Davignon, Jeffrey S. Cohn   +6 more
doaj  

Volunteer Participation in the Health eHeart Study: A Comparison with the US Population. [PDF]

, 2017
Direct volunteer "eCohort" recruitment can be an efficient way of recruiting large numbers of participants, but there is potential for volunteer bias.
Guo, Xiaofan, Marcus, Gregory M, Olgin, Jeffrey E, Pletcher, Mark J, Vittinghoff, Eric   +4 more
core   +1 more source

Antibacterial hydrogel: The sniper of chronic wounds

BMEMat, EarlyView.
The treatment of chronic wounds has always been an important challenge in the medical field. We focus on hydrogels not only because they provide a moist healing environment but also because compared with traditional dressings, they can effectively prevent and treat infections, reduce wound pain and scar formation.
Shengtai Bian, Huijun Ye, Pan Wang, Changxing Li, Xutao Guo, Ming Guan, Shilun Feng   +6 more
wiley   +1 more source

Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c. [PDF]

, 2018
AimTo determine whether successful treatment with directacting antivirals (DAA) is associated with improvements in hemoglobin A1c (HbA1c) and if type 2 diabetes mellitus (T2DM) or metabolic syndrome affects sustained virologic response (SVR).MethodsWe ...
Aby, Elizabeth S, Benhammou, Jihane N, Dong, Tien S, Han, Steven-Huy, Kawamoto, Jenna, May, Folasade P, Pisegna, Joseph R   +6 more
core  

A joint regression modeling framework for analyzing bivariate binary data in R [PDF]

, 2017
We discuss some of the features of the R add-on package GJRM which implements a flexible joint modeling framework for fitting a number of multivariate response regression models under various sampling schemes.
Marra, G., Radice, R.
core   +3 more sources