Results 171 to 180 of about 244,171 (297)

Metabolic Signatures and Diagnostic Prediction Models for Coronary Artery Disease and Type 2 Diabetes Mellitus: Insights From an Exploratory Study

iNew Medicine, EarlyView.
Metabolomic & lipidomic analysis reveals metabolic overlap between CAD & T2DM, highlighting 7 key metabolites as potential biomarkers. A predictive model based on these achieves high accuracy, potentially advancing precision medicine & metabolic insights.
Zhihua Wang, Meiming Su, Ying Li, Yapei Li, Shuo Chen, Ting Peng, Hans Strijdom, Jiangang Wang, Jianping Weng, Suowen Xu   +9 more
wiley   +1 more source

Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis. [PDF]

J Transl Med
Li L, Sun W, Tan T, Xu J, Chen Y, Chen Y, Gao G, Ai X, Zhou J, Li Y, Zhang D, Lei S.   +11 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Hyperlipidemia in membranous nephropathy. [PDF]

Clin Kidney J
Zhang M, Liu WL, Xu G, Dong L.
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Large‐Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

Journal of Clinical Laboratory Analysis, EarlyView.
Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou, Shandra Jones, Juan Montes, Jonathan Ritter, Li‐Yu Shih, Chia‐Jung Chan, Ying‐Chou Lin, Min Chen, Shih‐Yin Chen, Ning Wu   +9 more
wiley   +1 more source

Sex differences in 5‐year incidence and prevalence of physical illnesses following early childhood autism diagnosis

JCPP Advances, EarlyView.
Abstract Background Sex differences in the clinical presentation of autism are established, but evidence on early‐life co‐occurring physical illnesses in early‐diagnosed autistic individuals is scarce. This nationwide cohort study examined sex‐stratified incidence of physical illnesses within 5 years after autism spectrum disorder (ASD) diagnosis in ...
Yu‐Chieh Chuang, Yu‐Jui Huang, Meng‐Chuan Lai, Wen‐Yin Chen, Chun‐Hung Pan, Sheng‐Siang Su, Chian‐Jue Kuo   +6 more
wiley   +1 more source

Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta‐Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steatotic liver disease (SLD) is an unrecognized complication after pancreaticoduodenectomy (PD) and may affect nutrition and long‐term recovery. This meta‐analysis estimated the incidence of SLD after PD and identified its clinical and surgical risk factors.
Ronnakorn Kongsakon, Wasit Wongtrakul, Khemajira Karaketklang, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya   +4 more
wiley   +1 more source

Pulsatility Assessment of Cerebral Perforating Arteries Using Submillimeter‐Resolution Dual‐VENC Phase‐Contrast MRI at 3T

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Dysfunction of cerebral perforating arteries is a major contributor to cerebral small vessel disease. Developing a reliable MRI technique for assessing cerebral perforating arteries on widely accessible 3T systems would be advantageous.
Jianing Tang, Sang Hun Chung, Maria Gamez, Tianrui Zhao, Michael S. Wolf, Dilip K. Pandey, Philip B. Gorelick, Lirong Yan   +7 more
wiley   +1 more source