Results 11 to 20 of about 244,171 (297)
Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia
Frontiers in Cellular and Infection Microbiology, 2021 Hyperlipidemia, defined as the presence of excess fat or lipids in the blood, has been considered as a high-risk factor and key indicator of many metabolic diseases.
Xiaokang Jia, Wen Xu, Xiaoyan Li
exaly +3 more sources
Indian Heart JournalThe leading cause of mortality worldwide is atherosclerotic cardiovascular disease. Atherosclerotic plaques are well known to originate early in the childhood.
Ankit Garg, S. Radhakrishnan
doaj +3 more sources
Redox Biologyα-Ketoglutarate (AKG), a crucial intermediate in the tricarboxylic acid cycle, has been demonstrated to mitigate hyperlipidemia-induced dyslipidemia and endothelial damage.
Jiankang Liu
exaly +3 more sources
Pediatrics In Review, 2020 Cardiovascular disease remains the top cause of morbidity and mortality in the United States. Atherosclerotic plaques are known to start in adolescence, and, therefore, young adults can be affected by coronary artery disease. Children with known risk factors, such as genetic predisposition, including familial hyperlipidemias, diabetes, and renal ...
Jeremy, Stewart +4 more
openaire +3 more sources
BMC Pharmacology and Toxicology, 2021 Background Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have become significant global health concerns. In the present study, we aimed to investigate the effects of saroglitazar, a dual PPARα/γ agonist, fenofibrate ...
Rasoul Akbari +5 more
doaj +1 more source
Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L [PDF]
Cell Journal, 2022 Objective: In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region aswell. Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor type1 (PAI-1) which ...
hossein babaahmadi rezaei +2 more
doaj +1 more source
BMC Research Notes, 2022 Objective Non-alcoholic steatohepatitis (NASH) has become a global medical problem. Currently, there is no approved pharmacologic treatment for this condition.
Rasoul Akbari +4 more
doaj +1 more source
Changes in the prevalence, treatment and control of hypertension in Germany? : a clinical-epidemiological study of 50.000 primary care patients [PDF]
, 2012 INTRODUCTION: Medical societies have developed guidelines for the detection, treatment and control of hypertension (HTN). Our analysis assessed the extent to which such guidelines were implemented in Germany in 2003 and 2001. METHODS: Using standardized
Einsle, Franziska +11 more
core +5 more sources
EGF Receptor Transactivation by Endothelin-1 Increased CHSY-1 Mediated by NADPH Oxidase and Phosphorylation of ERK1/2 [PDF]
Cell Journal, 2021 Objective: Growth factors [transforming growth factor-β (TGF-β), epidermal growth factor (EGF), endothelin-1 (ET-1)] stimulate proteoglycan synthesis resulting in retention and accumulation of low density lipoprotein (LDL) in vessel intima and leading to
Hossein Babaahmadi-Rezaei +5 more
doaj +1 more source
BMC Research Notes, 2020 Objectives This study focused on the beneficial effects of Capparis spinosa (CS) treatment on the steatohepatitis induced by the administration of a high-fat emulsion in rats.
Rasoul Akbari +4 more
doaj +1 more source