Results 81 to 90 of about 254,702 (346)

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels [PDF]

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Ayoubi, T.A., Bruin, T.W., Feskens, E.J.M., Glembotski, C.C., Greevenbroek, M.M., Heldens, J., Hofker, M.H., Kallen, C.J., Kuusisto, J., Laakso, K., Meex, S.J., Pajukanta, P., Schalkwijk, C.G., Sinsheimer, J.S., Stehouwer, C.D., Taskinen, M.R., Thuerauf, D.J., Vlietinck, R., Weissglas-Volkov, D., Wouters, B.G.   +19 more
core   +1 more source

Multi‐scale Engineered Vasculature and Hierarchical Porosity via Volumetric Bioprinting‐Guided Photopolymerization‐Induced Phase Separation

Advanced Materials, EarlyView.
Vascularization in bioprinted hydrogels is limited by nanoscale porosity in hydrogel bionks. Volumetric bioprinting of gelatin–norbornene phase‐separating hydrogels permits to create centimeter‐scale constructs featuring interconnected multi‐scale porosity. Light dose gradients result in spatially controlled pore dimensions. Capillary‐scale vessels are
Oksana Y. Dudaryeva, Maj‐Britt Buchholz, Gabriel Größbacher, Sofia Amaral, Sammy Florczak, Camille Bonhomme, Alvaro Rojo Ferrer, Mark W. Tibbitt, Riccardo Levato   +8 more
wiley   +1 more source

Sudden cardiac death in patients with ischemic heart failure undergoing coronary artery bypass grafting results from the STICH randomized clinical trial (Surgical Treatment for Ischemic Heart Failure) [PDF]

, 2017
Background—The risk of sudden cardiac death (SCD) in patients with heart failure following CABG has not been examined in a contemporary clinical trial of surgical revascularization. This analysis describes the incidence, timing and clinical predictors of
Al-Khatib, Sana M., Carson, Peter E., Cleland, John G.F., Desvigne-Nickens, Patrice M., Feldman, Arthur M., Lang, Irene M., Lee, Kerry L., Nicolau, Jose C., Pokorney, Sean, Rao, Meena P., Romanov, Alexander, Rouleau, Jean L., Selzman, Craig H., She, Lilin, Siepe, Matthias, Stepinska, Janina, Sueta, Carla, Tungsubutra, Wiwun, Velazquez, Eric J., Yii, Michael   +19 more
core   +2 more sources

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Elevated Interleukin-38 Level Associates with Clinical Response to Atorvastatin in Patients with Hyperlipidemia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. And it is tightly related to chronic inflammation. Interleukin-38 (IL-38) represents a new member of anti-inflammatory cytokines.
Ning Yang, Yanqiu Song, Bo Dong, Yang Li, Lu Kou, Jingyu Yang, Qin Qin   +6 more
doaj   +1 more source

A pilot study of temsirolimus and body composition. [PDF]

, 2013
PurposeBody weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss ...
Janku, Filip, Kurzrock, Razelle, Naing, Aung, Parsons, Henrique A, Tsimberidou, Apostolia M, Veasey-Rodrigues, Heloisa, Wheler, Jennifer J   +6 more
core   +2 more sources

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

First Evaluation of an Index of Low Vagally-Mediated Heart Rate Variability as a Marker of Health Risks in Human Adults: Proof of Concept. [PDF]

, 2019
Multiple studies have demonstrated low vagally-mediated heart rate variability (HRV) being associated with a range of risk factors for heart disease and stroke, including inflammation, hyperglycemia, hyperlipidemia, and hypertension.
Fischer, Joachim E, Jarczok, Marc N, Koenig, Julian, Thayer, Julian F, Wittling, Arne   +4 more
core   +2 more sources

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia

Frontiers in Physiology, 2019
Clinical gestational diabetes mellitus (GDM) is frequently associated with hyperlipidemia comorbidity. Altered human gut microbiome has been linked to GDM and hyperlipidemia, respectively but not the comorbid condition. We hypothesize that the occurrence
He Liu, He Liu, Li-Long Pan, Siting Lv, Qin Yang, Hao Zhang, Hao Zhang, Wei Chen, Wei Chen, Zhuwu Lv, Jia Sun, Jia Sun   +11 more
doaj   +1 more source