Results 81 to 90 of about 2,306,494 (185)

Pain Severity Trajectories and Patient Profiles in Chronic Pain Patients Treated with Cannabis‐Based Medicinal Products: A k‐Means Clustering Analysis of the UK Medical Cannabis Registry

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Cannabis‐based medicinal products (CBMPs) are increasingly prescribed for chronic pain, yet the supporting evidence remains limited and the extent to which patients differ in their response is poorly understood. This study applied longitudinal k‐means clustering to pain‐severity trajectories in patients treated with CBMPs for chronic pain to ...
Simon Erridge, Aritra Datta, Aditya Mukherjee, Dhruv Vasooja, Ross Coomber, Sushil Beri, Shaheen A. Khan, Mark W. Weatherall, Michael W. Platt, James J. Rucker, Pedro A. M. Mediano, Mikael H. Sodergren   +11 more
wiley   +1 more source

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

Movement Disorders, Volume 41, Issue 10, Page 2755-2766, October 2026.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard, Lucy Dougherty‐de Miguel, German Demidov, Galuh Astuti, Amaia Lasa‐Aranzasti, Ana Cueto‐González, Marta Correa‐Vela, Carlos Lázaro‐Hernández, Charlotte A. Haaxma, Clara D.M. van Karnebeek, David Gómez‐Andrés, Ignacio Iglesias‐Serrano, Jiddeke M. van de Kamp, Jolanda Schieving, Laura Trujillano, Marc Engelen, Beatriz Muñoz‐Cabello, Roderick P.P.W.M. Maas, Thatjana Gardeitchik, Victoria Gonzalez, Annemarie de Vreugd, Cristina Pérez‐Sanchez, Elisabet Lloveras, Erik‐Jan Kamsteeg, Maartje Pennings, Natalia Rey‐Viñets, Javier Sánchez, Ronald van Beek, Antonio Moreno‐Galdó, Lisenka E.L.M. Vissers, Kornelia Neveling, Anna Marcé‐Grau, Machteld M. Oud, Belén Pérez‐Dueñas   +33 more
wiley   +1 more source

DOES PLANTAR PRESSURE AND LOADING PATTERN VARY WITH JOINT HYPERMOBILITY IN YOUNG FEMALES?

, 2021
Background: Joint hypermobility is a connective tissue disorder that increases joint range of motion. Plantar pressure and foot loading patterns may change with joint hypermobility.
ÖZKAN, ÖMER, Yilmaz, Seval, KORKUSUZ, FEZA, Babayeva, Naila, TORĞUTALP, ŞERİFE ŞEYMA, Babayeva, N, Seval Yilmaz, Feza Korkusuz, Yılmaz, S, Naila Babayeva, Gürhan Dönmez, Dönmez, GÜRHAN, Torgutalp, SS, Şerife Şeyma Torgutalp, Ömer Özkan, Korkusuz, F, Özkan, Ö   +16 more
core   +1 more source

Mosaicism for Cohen–Gibson Syndrome in a Female Individual With Overgrowth and Neurodevelopmental Delay

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
Postzygotic EED mosaicism: c.1091G > T; p.(Trp364Leu) in a 12‐year‐old female with overgrowth–intellectual disability syndrome (Cohen–Gibson syndrome). Variant allele fractions: 31% blood, 30% saliva, 11%–17% buccal mucosa. This expands the spectrum of EED‐related disorders, highlighting mosaic screening for diagnosis, counselling, and future therapies.
Fei Song, Manuel Michels, Beate Betz, Walburga Vorhoff, Teresa Neuhann, Lisa Senninger, Dagmar Wieczorek   +6 more
wiley   +1 more source

Variable Phenotypic Manifestations of Novel Compound Heterozygous CRPPA Variants in Two Iranian Siblings With Limb‐Girdle Muscular Dystrophy

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
A novel compound heterozygous CRPPA genotype (missense variant and exon 9‐10 deletion) identified in two siblings resulted in marked intrafamilial phenotype variability, ranging from childhood‐onset to late‐onset muscular dystrophy, highlighting the importance of combined SNV and CNV analysis.
Parnian Alagha, Fatemeh Ahangari, Ariana Kariminejad, Aida Ghasemi, Soheila Gholami, Neda Sadatian, Roxana Kariminejad, Kimia Kahrizi, Ali Asghar Okhovat, Hossein Najmabadi   +9 more
wiley   +1 more source

Visual, vestibular, and ocular motor changes during nitroglycerin‐triggered vestibular migraine

Headache: The Journal of Head and Face Pain, Volume 66, Issue 9, Page 1991-2005, October 2026.
Plain Language Summary Vestibular migraine (VM) is a common cause of intermittent dizziness, but there have been no studies with provoked (induced) VM used to characterize how the vestibular and ocular (vision) systems interact. We injected 20 patients with VM with nitroglycerin to provoke an attack and used a specialized camera to record their eye ...
Maria Dolores Villar‐Martinez, Francesca Puledda, Caroline Domingos‐Belo, Adolfo M. Bronstein, Peter J. Goadsby   +4 more
wiley   +1 more source

Rates of mental health concerns among individuals assessed at the GoodHope Ehlers-Danlos Syndrome Clinic

Orphanet Journal of Rare Diseases
Past research has indicated that individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobililty Spectrum Disorder (G-HSD) report psychological and psychiatric symptoms, particularly anxiety disorders and depressive symptoms, at much ...
P. Maxwell Slepian, Kristina Axenova, Molly McCarthy, Rachel Siegal, Keisha Gobin, Aliza Weinrib, Stephanie Buryk-Iggers, Daniel Santa Mina, Laura McGillis, Nimish Mittal, Joel Katz, Hance Clarke   +11 more
doaj   +1 more source

Late Recognition of Suspected Ehlers‐Danlos Syndrome After Recurrent Small‐Bowel Perforations: A Case Report

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT Background Ehlers‐Danlos syndrome (EDS) may be overlooked when gastrointestinal and musculoskeletal findings are assessed separately. Case Presentation An older woman with two previous small‐bowel perforations had bilateral congenital hip dislocation, recurrent shoulder dislocations, skin hyperextensibility, and muscularis propria thinning in ...
Norio Horiguchi, Etsuko Hisanaga, Hiroko Sato, Kuniko Yoshida, Akihito Kimura, Ayumi Ito, Miki Horita, Aya Suzuki, Keiko Kawai‐Kowase   +8 more
wiley   +1 more source

Autism Spectrum Disorders and Ehlers-Danlos Syndrome Hypermobility-Type: Similarities in clinical presentation

, 2016
Autism Spectrum Disorder (ASD) is an etiologically and clinically heterogeneous group of neurodevelopmental conditions, characterized by impairments in communication, social interaction and restricted repetitive and stereotyped behaviors.
Brissot, Régine, Hamonet, Claude, Baghdadli, Amaria, Baeza Velasco, Carolina   +3 more
core  

Data_Sheet_1_The Relationship Between Generalised Joint Hypermobility and Autism Spectrum Disorder in Adults: A Large, Cross-Sectional, Case Control Comparison.zip

, 2022
Autism spectrum disorder (ASD) and generalised joint hypermobility (GJH) share a number of clinical manifestations including proprioceptive impairment, motor difficulties, sensory hypersensitivity, and autonomic dysfunction. Clinical observations suggest
Nils Thelin (12058706), Mats B. Humble (8592411), Martin R. Glans (12058703), Marie Elwin (6708758), Susanne Bejerot (518053)   +4 more
core   +1 more source