Results 211 to 220 of about 110,596 (265)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Predicting Mechanical Strength of Alkali-Activated High-Performance Concrete Using Machine-Learning Methods. [PDF]

Materials (Basel)
Biswas R, Kazemi F, Sharma A, Jankowski R, Asteris PG.   +4 more
europepmc   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Bayesian Umbrella Quadrature Automates Free-Energy Calculations Across Diverse Molecular Systems and Processes. [PDF]

J Chem Theory Comput
Kempkes EK, Pérez de Alba Ortíz A.
europepmc   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Machine learning-based modeling for precise runoff forecasts in hydrological systems. [PDF]

Sci Rep
Aldrees A, Siddiq B, Javed MF.
europepmc   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Simulation-informed kernel-based regression models for predicting temperature distribution in microwave hyperthermia. [PDF]

Sci Rep
Alazwari MA, Abu-Hamdeh NH, Almitani KH.
europepmc   +1 more source

Temperature‐Modulated MEMS Gas Sensor Array Enabled by Physics‐Informed Deep Learning for Thermal‐Runaway Characteristic Gas Discrimination

Advanced Science, EarlyView.
This work presents a 2 × 2 integrated single‐chip MEMS gas sensor array with temperature modulation and deep learning for discriminating thermal‐runaway characteristic gases. The array generates distinct temperature‐modulated response patterns for four characteristic gases (H2, CO, CH4, and CO2), while a HK‐MoE model is developed to achieve robust ...
Qin Luo, Qi Guo, Rongyue Liu, Yilin Li, Haiping Zhu, Wei Zhang, Zhongren Chen, Zhaojun Liu, Xing Cheng   +8 more
wiley   +1 more source