Results 141 to 150 of about 46,859 (313)

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Embryo Evaluation Based on ResNet with AdaptiveGA-optimized Hyperparameters

, 2022
Wenju Zhou Wenju Zhou, Xiaofei Han Wenju Zhou, Yuan Xu Xiaofei Han, Rongfei Chen Yuan Xu, Zhenbo Zhang Rongfei Chen   +4 more
openalex   +2 more sources

Development of physical property prediction models for polypropylene composites with optimizing random forest hyperparameters [PDF]

, 2021
Chonghyo Joo, Hyundo Park, Jongkoo Lim, Hyungtae Cho, Junghwan Kim   +4 more
openalex   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

Multi-Objective Hyperparameter Optimization on Gradient Boosting for Breast Cancer Detection [PDF]

, 2023
Priya Singh, Swayam Gupta, Vasu Gupta
openalex   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Hyperparameter optimization of hp-greedy reduced basis for gravitational wave surrogates [PDF]

, 2023
Franco Cerino, Andrés Diaz-Pace, Emmanuel Tassone, Manuel Tiglio, Atuel Villegas   +4 more
openalex   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

An Efficient Neural Network for Segmenting Multiple Joint Tissues from Knee MRI with Hyperparameter Optimization: Data from the Osteoarthritis Initiative

, 2022
Pauline Shan Qing Yeoh, Siew Li Goh, Khairunnisa Hasikin‬, Xiang Wu, Samiappan Dhanalakshmi, Khin Wee Lai   +5 more
openalex   +1 more source