Results 61 to 70 of about 22,618 (258)

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

open access: yesFundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo   +9 more
wiley   +1 more source

Macroprolactinemia in patients with hyperprolactinemia: an experience from a single tertiary center

open access: yesThe Pan African Medical Journal, 2020
Macroprolactinemia frequently causes misdiagnosis, unnecessary investigation and inappropriate treatment in hyperprolactinemic patients. Aim of this study is to investigate the prevalence and clinical characteristics of Thai patients with ...
Phronpan Chutpiboonwat   +5 more
doaj   +1 more source

Abnormal DNA Methylation Profile Suggests the Extension of the Clinical Spectrum of the SETD2 ‐Related Disorders to a Syndromic Multiple Tumor Phenotype

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT SETD2 has an essential role in epigenetic regulation. SETD2 pathogenic variants cause neurodevelopmental disorders (SETD2‐NDDs) that most commonly include various degrees of intellectual disability and behavioral disorders, macrocephaly, brain malformations, and generalized overgrowth.
Marie Lucain   +11 more
wiley   +1 more source

Morphological and immunohistochemical features of placenta in postpartum women with hyperprolactinemia history

open access: yesPatologìâ, 2020
Hyperprolactinemia (HP) is a persistent increase in serum prolactin levels, the most typical manifestation of which is a dysfunction of the reproductive system.
T. D. Zadorozhna   +3 more
doaj   +1 more source

Revisiting Late‐Onset Bipolar Disorder Associated With Pituitary Adenoma: A Cross‐Sectional, Multidisciplinary, Case‐Based Analysis

open access: yesBrain and Behavior, Volume 15, Issue 6, June 2025.
Surveying 300 neurologists, psychiatrists, and family physicians, this study demonstrates discipline‐specific strengths‐imaging (neurology), diagnosis (psychiatry), and pharmacological follow‐up (family medicine)‐yet persistent gaps in holistic care of late‐onset bipolar disorder in elders.
Yagmur Sever Fidan   +6 more
wiley   +1 more source

Retrospective Analysis of Cushing’s Disease with or without Hyperprolactinemia

open access: yesInternational Journal of Endocrinology, 2014
Objective. We compared the characteristics of patients with Cushing’s disease alone with those of patients with Cushing’s disease and hyperprolactinemia. Methods. Eighty-four patients were enrolled between 2002 and 2011, in a hospital in China. Clinical,
Cheng Huan   +4 more
doaj   +1 more source

Sexual Dysfunction as a Side Effect of Hyperprolactinemia in Methadone Maintenance Therapy [PDF]

open access: yes, 2013
Although endocrine abnormalities are recognized in opiate users, very little is known about the range of hormones affected, their pathophysiology and their clinical relevance.
Spasovska Trajanovska, Aneta   +4 more
core   +1 more source

Efficacy and safety of JMT103 in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial

open access: yesInternational Journal of Cancer, Volume 156, Issue 11, Page 2178-2187, 1 June 2025.
What's new? Bone metastases are common in a variety of cancer types, causing increased pain and worse outcomes. Suppression of bone turnover, such as with the monoclonal antibody denosumab, results in fewer skeletal complications and improved prognosis. Here, the authors demonstrate the safety and efficacy of a similar antibody, JMT103. Like denosumab,
Ran Ran   +15 more
wiley   +1 more source

Imaging Assessment of the Pituitary Gland and Long‐Term Endocrinological Abnormalities in Pediatric Brain Cancer Survivors

open access: yesJournal of Magnetic Resonance Imaging, Volume 61, Issue 6, Page 2516-2522, June 2025.
Background Pediatric brain cancer survivors often experience hypothalamic–pituitary dysfunction due to cranial irradiation and chemotherapy. While hormone deficiencies have been studied, the changes in pituitary size and shape on long‐term MRI and their relationship to endocrine dysfunction remain under‐explored.
Feras Qawasmi   +8 more
wiley   +1 more source

Association of polymorphic variants of DRD2 and DRD3 genes with development of neuroleptic hyperprolactinemia in patients with schizophrenia [PDF]

open access: yes, 2017
Hyperprolactinemia is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine receptors in the pituitary gland. We describe the association between hyperprolactinemia and a set of SNPs from DRD2 and DRD3 receptor genes
Бойко, А. С.   +2 more
core  

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