Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Therapy of asthma and Hypersensitivity Responses
Abstract An improper reaction against harmless environmental proteins causes allergies. All around the world, allergic disorders have become epidemics. The pathophysiology of allergic hypersensitivity reactions is significantly influenced by allergen-specific T helper (Th) cells.
openaire +1 more source
An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer
Advanced Science, EarlyView.Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li +11 more
wiley +1 more source
Different Light Wavelengths Differentially Influence the Progression of the Hypersensitive Response Induced by Pathogen Infection in Tobacco. [PDF]
Antioxidants (Basel)Tran BQ, Nguyen AT, Jung S.
europepmc +1 more source
Genome-Wide Identification Reveals That Nicotiana benthamiana Hypersensitive Response (HR)-Like Lesion Inducing Protein 4 (NbHRLI4) Mediates Cell Death and Salicylic Acid-Dependent Defense Responses to Turnip Mosaic Virus. [PDF]
Front Plant Sci, 2021 Wu X +13 more
europepmc +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
A hypersensitive response-like lesion-inducing protein modulates basal immunity against grey leaf spot in maize. [PDF]
Plant Biotechnol JZhong T +5 more
europepmc +1 more source
The RsRlpA Effector Is a Protease Inhibitor Promoting Rhizoctonia solani Virulence through Suppression of the Hypersensitive Response. [PDF]
Int J Mol Sci, 2020 Charova SN +5 more
europepmc +1 more source
Advanced Science, EarlyView.A scalable process converts para‐aramid fibers into soft‐magnetic building blocks via micrometer‐thick Fe0.64Ni0.36 (Invar‐type) coatings. Assembled into paper, they form a hierarchical conductive network whose tunable permeability enables thin, lightweight microwave absorption in the low‐frequency (S‐band) regime.
You Wu +7 more
wiley +1 more source
Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang +11 more
wiley +1 more source