Results 71 to 80 of about 5,468,337 (294)

In Vitro Lymphocyte Responses in Contact Hypersensitivity

Journal of Investigative Dermatology, 1970
Contact hypersensitivity to dinitrofluorobenzene (DNFB) was developed in guinea pigs. Lymphocytes from sensitive or insensitive donors were obtained from lymph nodes and cultured in the presence of conjugates of DNFB and protein extracts of guinea pig epidermis.
openaire   +4 more sources

Nitrate reductase dependent accumulation of nitric oxide is not required for the hypersensitive disease response in arabidopsis

, 2004
Molecular and genetic analysis has demonstrated that production and accumulation of nitric oxide by nitrate reductase is not required during hypersensitive resistance response in Arabidopsis ...
DELLEDONNE, Massimo, ZANINOTTO, Federica, Romero Puertas AC, Perazzolli M   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Novel Protein Elicitor PeBL2, from Brevibacillus laterosporus A60, Induces Systemic Resistance against Botrytis cinerea in Tobacco Plant

The Plant Pathology Journal, 2019
Here, we reported a novel secreted protein elicitor PeBL2 from Brevibacillus laterosporus A60, which can induce hypersensitive response in tobacco (Nicotiana benthamiana). The ion-exchange chromatography, high-performance liquid chromatography (HPLC) and
Ghulam Hussain Jatoi, Guo Lihua, Yang Xiufen, Muswar Ali Gadhi, Azhar Uddin Keerio, Yusuf Ali Abdulle, Dewen Qiu   +6 more
doaj   +1 more source

A newly identified glycosyltransferase AsRCOM provides resistance to purple curl leaf disease in agave

BMC Genomics, 2023
Background Purple curl leaf disease brings a significant threat to the development of agave industry, the underlying mechanism of disease-resistant Agave sisalana. hybrid 11648 (A. H11648R) is still unknown.
Zhiwei Lu, Xiaowan Hou, Zhi Ke, Yanmei Zhang, ZiPing Yang, Wenzhao Zhou   +5 more
doaj   +1 more source

Nitric Oxide Signaling during the Hypersensitive Disease Resistance Response.

, 2016
Nitric oxide (NO) signaling is known to play a key role in triggering the hypersensitive response (HR) of plants to avirulent pathogens. In this chapter, we have summarized what is currently known about the role of NO in this important biological context.
LING, Tengfang, Zahra Imanifard, DELLEDONNE, Massimo, VANDELLE, Elodie Genevieve Germaine, BELLIN, Diana, Ruitao Liu, Tengfang Ling, Massimo Delledonne, Elodie Vandelle, Diana Bellin, Imanifard, Zahra, LIU, RUITAO   +11 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Agrobacterium-induced hypersensitive necrotic reaction in plant cells: a resistance response against Agrobacterium-mediated DNA transfer [PDF]

, 2005
High necrosis and poor survival rate of target plant tissues are some of the major factors that affect the efficiency of Agrobacterium-mediated T-DNA transfer into plant cells.
Tripathi, Leena, Kuta, Danladi Dada
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The C-Terminal Half of the HrpN Virulence Protein of the Fire Blight Pathogen Erwinia amylovora Is Essential for Its Secretion and for Its Virulence and Avirulence Activities

Molecular Plant-Microbe Interactions, 2008
The HrpN (harpin) protein of the fire blight pathogen Erwinia amylovora is an essential virulence factor secreted via the bacterial type III secretion system. HrpN also has avirulence activity when delivered to tobacco by E.
Judith P. Sinn, Chang-Sik Oh, Philip J. Jensen, Sara C. D. Carpenter, Steven V. Beer, Timothy W. McNellis   +5 more
doaj   +1 more source