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Biomedicines, 2023 Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu +3 more
doaj +2 more sources
Delayed hypersensitivity reactions to taxanes: Clinical presentation and outcomes of post-medication and rapid drug desensitization [PDF]
World Allergy Organization JournalBackground: Taxanes are widely used in solid tumors but may induce delayed hypersensitivity reactions (DHRs), potentially compromising treatment. The aim was to characterize taxane-related DHRs and evaluate the role of post-medication and rapid drug ...
Rosalaura Villarreal-González, MD, PhD +6 more
doaj +2 more sources
Delayed Drug Hypersensitivity Reactions
Annals of Internal Medicine, 2003 Immune reactions to small molecular compounds, such as drugs, can cause a variety of diseases involving the skin, liver, kidney, and lungs. In many drug hypersensitivity reactions, drug-specific CD4+ and CD8+ T cells recognize drugs through their alphabeta T-cell receptors in an MHC-dependent way. Drugs stimulate T cells if they act as haptens and bind
W. Pichler
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DELAYED HYPERSENSITIVITY [PDF]
The Journal of Experimental Medicine, 1968 Exposure to picryl guinea pig albumin with 3–6 picryl groups per mole failed to affect the ability of peritoneal exudate or peripheral blood leukocytes from sensitized donors to transfer delayed sensitivity to normal recipients. In contrast, conjugates containing 40–48 picryl groups per mole altered the ability of exposed leukocytes to transfer delayed
John P Phair, Fred S Kantor
+4 more sources
Swiss Medical Weekly, 2023 BACKGROUND: Corticosteroids, which are anti-inflammatory and immunosuppressive agents used for the treatment of various diseases including allergic disorders, can induce immediate and delayed hypersensitivity reactions.
Keren Mahlab-Guri +2 more
doaj +1 more source
Delayed Localized Hypersensitivity Reactions to the Moderna COVID-19 Vaccine: A Case Series.
JAMA dermatology, 2021 Importance In response to the coronavirus disease 2019 (COVID-19) pandemic, 2 mRNA vaccines (Pfizer-BioNTech and Moderna) received emergency use authorization from the US Food and Drug Administration in December 2020.
Margaret S. Johnston +3 more
semanticscholar +1 more source
Pharmacological prevention of delayed hypersensitivity reactions caused by iodinated contrast media
World Allergy Organization Journal, 2021 Background: Delayed hypersensitivity reactions (DHRs) to radiocontrast media (RCM) occur in approximately 0.5–23.0% of patients and are thought to be caused by T cell-mediated mechanisms. However, an optimal pharmacological preventive strategy is not yet
Jung-Hyun Kim +7 more
doaj +1 more source
An Updated Review of the Diagnostic Methods in Delayed Drug Hypersensitivity
Frontiers in Pharmacology, 2021 Delayed drug hypersensitivity reactions are clinically diverse reactions that vary from isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug discontinuation or even continued drug treatment, to the other extreme of ...
A. Copaescu +4 more
semanticscholar +1 more source
Allergology International, 2022 Background: Skin rash often occurs upon oral administration of amoxicillin in children, due to non-immediate hypersensitivity. However, information on delayed hypersensitivity to amoxicillin is scarce.
Yukiko Katoh +5 more
doaj +1 more source
Delayed Hypersensitivity [PDF]
Science, 1960 The capacity to develop the delayed type of hypersensitivity to diphtheria toxoid and ovalbumin may persist in guinea pigs and rabbits that have received doses of x-ray sufficient to eliminate a detectable antibody response. Larger doses of x-irradiation can prevent development of delayed-type hypersensitivity in rabbits.
A J, Crowle +3 more
openaire +4 more sources