Results 231 to 240 of about 2,340,035 (348)

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

When prophylaxis turns pathologic: a case of LMWH-induced necrosis with secondary cellulitis. [PDF]

Oxf Med Case Reports
AbuBaha M, AbuBaha B, Salameh H, Afana A, Abseh I, Taha H.   +5 more
europepmc   +1 more source

Final Analysis of the Phase 1/2 Trial of Valoctocogene Roxaparvovec for Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5 (AAV5)‐mediated gene therapy for severe haemophilia A (HA). Aim Report the final safety and efficacy results of the phase 1/2 trial of valoctocogene roxaparvovec. Methods An open‐label phase 1/2 trial (NCT02576795) enrolled adult males with severe HA (factor
Priyanka Raheja, Savita Rangarajan, Will Lester, Bella Madan, Glenn F. Pierce, Emily Symington, Carolyn Millar, Dane Osmond, Mingjin Li, Konstantia‐Maria Chavele   +9 more
wiley   +1 more source

Late-onset polyvinylpyrrolidone allergy in a long-term hemodialysis patient: a case report of dialysis hypotension and gastrointestinal symptoms. [PDF]

CEN Case Rep
Narita T, Hara T, Yuki Y, Naganuma T, Ozaki A, Bando Y, Sato M, Komatsu M, Okazaki M, Hattori M, Kawaguchi H.   +10 more
europepmc   +1 more source

Severe Hair Dye Anaphylaxis Caused by Toluene‐2,5‐ Diamine Identified by Positive in Vitro Tests

Contact Dermatitis, EarlyView.
Eglė Janušonytė, Thomas Harr, Pierre Piletta, Sophie Vandenberghe‐Dürr   +3 more
wiley   +1 more source

Chronic ulcerative oesophagitis rich in IgG4‐positive plasma cells – a distinct clinicopathological entity

Histopathology, EarlyView.
We report a series of 12 patients (mean age 63 years) with chronic oesophageal ulceration showing morphological features of IgG4‐related inflammatory disease. Most patients underwent several rounds of endoscopy until this association was recognized. The majority of patients went into clinical and histological remission following corticosteroid therapy.
Hanna Henzinger, Ian Brown, Anthony J Gill, Tomas Slavik, Giuseppe Zamboni, Cord Langner   +5 more
wiley   +1 more source

Comprehensive assessment of allergic manifestations including drug hypersensitivity in adult patients with inborn errors of immunity. [PDF]

Allergy Asthma Proc
Korkmaz P, Toprak ID, Demir S, Yegit OO, Kahveci N, Hormet Igde M, Celik Kamaci S, Aslan AF, Atasever MD, Eyice Karabacak D, Sezgin ME, Guzel SE, Kaya E, Erden B, Kilinc Z, Imren Aksit IG, Bolek L, Unal D, Gelincik A.   +18 more
europepmc   +1 more source

Hydroxychloroquine Patch Test Positivity in a Patient With Systemic Lupus Erythematosus

Contact Dermatitis, EarlyView.
Alexa G. Ries, Zachary Frost, Zachary Hopkins, Jamie P. Schlarbaum   +3 more
wiley   +1 more source

Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin

International Journal of Cosmetic Science, EarlyView.
Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang, Hong Zhang, Chengming Zhang, Wencai Jiang, Luonan Chen, Yimei Tan, Ying Zou, Xuelan Gu   +7 more
wiley   +1 more source

Local Urticarial Reaction Above the Site of an Intravenous Cannula: Possible Allergy to Remimazolam in a Fourteen-Year-Old Adolescent. [PDF]

J Med Cases
Blake C, Corridore M, Khan S, Willer BL, Tobias JD.   +4 more
europepmc   +1 more source