Modeling cerebral palsy in animals
Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 158-174, February 2026.Abstract Advancements in the treatment of cerebral palsy depend on animal research. Yet, most animal models have not been fully evaluated for spasticity and dystonia using clinically relevant measures of altered tone or movement patterns, which form the basis for diagnosing people with the condition.
Katharina A. Quinlan +8 more
wiley +1 more source
Treatment of Histoplasmosis With Posaconazole in the Setting of a Severe Itraconazole Hypersensitivity Reaction: A Case Report. [PDF]
J Pharm TechnolJohannemann KM +5 more
europepmc +1 more source
Biochemical and Physiological Effects of Galanin in Health and Disease
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles +3 more
wiley +1 more source
The Silent Culprit: Drug-Induced Fever Associated With Trimethoprim-Sulfamethoxazole. [PDF]
CureusLages M +3 more
europepmc +1 more source
Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma
Advanced Science, Volume 13, Issue 3, 14 January 2026.IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang +16 more
wiley +1 more source
Clinical outcome of Nd:YAG laser and bioactive glass combined use for dentin hypersensitivity after scaling and root planning: a short-term comparative study. [PDF]
Eur J Med ResYan K +6 more
europepmc +1 more source
Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment
Cancer Medicine, Volume 15, Issue 1, January 2026.Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang +5 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Sinomenine, derived from Sinomenium acutum, is widely used in inflammatory diseases. However, its risk of inducing agranulocytosis is not widely appreciated. We report a life‐threatening case in a 40‐year‐old woman with chronic kidney disease (CKD; baseline estimated glomerular filtration rate [eGFR] as low as 36 mL/min/1.73 m2) who developed ...
Ping Xin, Ruoyan Liu, Yu Zhang, Bin Fu
wiley +1 more source
Hypersensitivity Reactions Associated With Aesthetic Botulinum Toxin A Injections: A Case Series. [PDF]
CureusBuchholz E +4 more
europepmc +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract Grapefruit juice (GFJ) is a known inhibitor of intestinal cytochrome P450 3A (CYP3A) metabolism leading to increased exposure to CYP3A substrates such as tacrolimus. The extended‐release tacrolimus formulation Envarsus (LCPT) exhibits prolonged absorption throughout the entire GI tract.
Adekunle Alabi +7 more
wiley +1 more source