Results 41 to 50 of about 2,776,276 (310)

Successful Dabrafenib Desensitization Protocols in a Patient with Metastatic Melanoma

Medicina, 2022
Dabrafenib and trametinib are two available molecules that have been approved for the treatment of metastatic melanoma with BRAF-V600E or V600K mutations.
Roxana Silvia Bumbacea, Selda Ali, Sabina Loredana Corcea, Dan Corneliu Jinga, Luiza Spiru   +4 more
doaj   +1 more source

Multivariate logistic regression model of predictors and risk scores of perioperative drug hypersensitivity reaction.

, 2022
Multivariate logistic regression model of predictors and risk scores of perioperative drug hypersensitivity reaction.
Ujal Pradhan (11944428), Maliwan Oofuvong (5922731), Orarat Karnjanawanichkul (11944431), Jatuporn Pakpirom (11944434)   +3 more
core   +1 more source

Hypersensitivity Reaction to Metal: A Bibliometric Study

SAGE Open Nursing, 2022
Background: To delineate the scientific publications on metal hypersensitivity. Methods: Scopus database from 1946 to 2020, written in English, Spanish, or Portuguese. This is a bibliometric study, with a descriptive and quantitative approach.
Tassia Teles Santana de Macedo PhD, RN, Itana Lúcia Azevêdo de Jesus Nursing student, Wilton Nascimento Figueredo PhD, RN, Dzifa Dordunoo PhD, RN   +3 more
doaj   +1 more source

Comparison of patient, surgical and anesthesia-related factors of mild to severe drug hypersensitivity reaction.

, 2022
Comparison of patient, surgical and anesthesia-related factors of mild to severe drug hypersensitivity reaction.
Ujal Pradhan (11944428), Maliwan Oofuvong (5922731), Orarat Karnjanawanichkul (11944431), Jatuporn Pakpirom (11944434)   +3 more
core   +1 more source

Delayed-type hypersensitivity skin reaction to Covid-19 vaccine

Journal of Family Medicine and Primary Care, 2021
Delayed-Type Hypersensitivity Skin Reaction following the Moderna mRNA COVID-19 Vaccine. This case is an unusually prolonged presentation of skin rash following vaccination for the novel COVID-19 virus.
Mia L Robb, Leo J Robb
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

HLA-B*5701 screening for hypersensitivity to Abacavir [PDF]

, 2008
Background Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to ...
Jagel-Guedes, E., Kozyrev, O., Phillips, E., Fitch, N., Thorborn, D., Molina, J-M, Hughes, A., Cid, J.F., Rugina, S., Nolan, D., Carosi, G., Hay, P., Ryan, S., Tomazic, J., Hughes, S., Benbow, A., Mallal, S., Workman, C.   +17 more
core  

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Acute coronary syndrome in diclofenac sodium-induced type I hypersensitivity reaction : Kounis syndrome [PDF]

, 2007
Drug-induced type I hypersensitivity reactions are frequent. Sometimes, acute coronary syndrome (ACS) can be registered in such patients, which may have a serious impact on the course and management of the allergic reaction.
Panic, Milos, Putnikovic, Biljana, Jankovic-Gavrilovic, Jelena, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Stojkovic, Aleksandra   +5 more
core