Results 151 to 160 of about 2,534,413 (315)

Effect of hydration schedules on dose‐limiting toxicity in patients with head and neck squamous cell carcinoma treated with cisplatin

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to determine if head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin chemoradiotherapy and short hydration (SH) experience less dose‐limiting toxicity (DLT) and receive more cisplatin than those with medium hydration (MH) or long hydration (LH).
Anouk W. M. A. Schaeffers, Cassimy B. van Neerven, Dorieke van Balen, Mirjam Crul, Marije Slingerland, Saskia A. C. Luelmo, Jan Paul de Boer, Jens Voortman, Arjan D. van Zuilen, Remco de Bree, Lot A. Devriese   +10 more
wiley   +1 more source

Gender-Specific Protection from Microvessel Rarefaction in Female Hypertensive Rats [PDF]

, 1998
Epidemiologic studies reveal that women have a significantly lower age-adjusted morbidity and mortality from cardiovascular disease than men, suggesting that gender is a cardiovascular disease risk factor.
Greene, Andrew S., Lombard, Julian H., Papanek, Paula E., Rieder, Mark J.   +3 more
core   +1 more source

Assessment of ethnic differences in pharmacokinetics and clinical responses of acalabrutinib between Chinese and White patients with B‐cell malignancies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to assess differences between Chinese and White patients in pharmacokinetics (PK) of, and clinical response to, acalabrutinib and its pharmacologically active major metabolite, ACP‐5862, to support recommended dosing in Chinese patients with B‐cell malignancies.
Tingting Yao, Junjie Ding, Shringi Sharma, Yunfei Li, Qianwei Xu, Peiming Ma   +5 more
wiley   +1 more source

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

Nature Communications
Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division.
Yu Yan, Hongbo Liu, Amin Abedini, Xin Sheng, Matthew Palmer, Hongzhe Li, Katalin Susztak   +6 more
doaj   +1 more source

Quality of life and perceived care of patients in advanced chronic kidney disease consultations: a cross-sectional descriptive study [PDF]

arXiv
Objetive: In the care of renal patients, prioritising their quality of life and nursing care is essential. Research links patients' perceptions of care quality to improved outcomes such as safety, clinical efficacy, treatment adherence, and preventive practices.
arxiv  

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Oral Fludrocortisone Test for Salt-Sensitive Screening in Hypertensive Patients: A Randomized Crossover Trial

International Journal of Hypertension, 2018
Background. Salt sensitivity is associated with an increased cardiovascular risk, but the gold standard method (diet cycles) requires 24-h urine samples and has poor patient compliance. Objectives.
Andrea Pio-Abreu, Isac de Castro, Giovanio Vieira da Silva, Katia Coelho Ortega, Decio Mion   +4 more
doaj   +1 more source

Anticoagulation intensity and outcomes among southeast‐Asians with moderate‐to‐severe mitral valve stenosis

British Journal of Clinical Pharmacology, EarlyView.
Objective To determine the optimal anticoagulation intensity of warfarin in a South‐East Asian population with moderate‐to‐severe rheumatic mitral stenosis. Methods A multicentre, retrospective study examined patients with rheumatic mitral stenosis who had not undergone valve replacement or repair and required long‐term warfarin therapy at two ...
Punyawee Puchsaka, Wipharak Rattanavipanon, Sararat Phetroong, Rudeekorn Ue‐sethasakdhi, Suparat Wattanasombat, Wattana Wongtheptien, Surakit Nathisuwan   +6 more
wiley   +1 more source

The tacrolimus concentration‐to‐dose ratio is associated with kidney function in heart transplant recipients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen, Teun B. Petersen, Boris C. A. Seijkens, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Brenda C. M. de Winter, Isabella Kardys, Dennis A. Hesselink, Olivier Manintveld   +9 more
wiley   +1 more source

Clinical Images: Penetrating aortic ulceration as an initial presentation of Erdheim‐Chester disease

Arthritis &Rheumatology, EarlyView.
Jerome Razanamahery, Bernard Bonnotte
wiley   +1 more source