Results 231 to 240 of about 2,904,733 (344)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

MANAGEMENT OF HYPERTENSION [PDF]

Malaysian Family Physician, 2011
WORKING GROUP CPG MANAGEMENT OF HYPERTENSION MOH MALAYSIA
doaj  

Factors associated with anxiety, depression, and cognitive impairment in individuals with hypertension: a cross-sectional study based on a Chinese population. [PDF]

Front Cardiovasc Med
Zhang X, Zhong X, Wang K, Shao Y, Wang Z, Jiao H.   +5 more
europepmc   +1 more source

2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).

European Heart Journal, 2013
G. Mancia, R. Fagard, K. Narkiewicz, J. Redón, A. Zanchetti, M. Böhm, T. Christiaens, R. Cífková, G. De Backer, A. Dominiczak, M. Galderisi, D. Grobbee, T. Jaarsma, P. Kirchhof, S. Kjeldsen, S. Laurent, A. Manolis, P. Nilsson, L. Ruilope, R. Schmieder, P. Sirnes, P. Sleight, M. Viigimaa, B. Waeber, F. Zannad, M. Burnier, E. Ambrosioni, M. Caufield, A. Coca, M. Olsen, C. Tsioufis, P. van de Borne, J. Zamorano, S. Achenbach, H. Baumgartner, Jeroen J. Bax, H. Bueno, V. Dean, C. Deaton, Ç. Erol, R. Ferrari, D. Hasdai, A. Hoes, J. Knuuti, P. Kolh, P. Lancellotti, A. Linhart, P. Nihoyannopoulos, M. Piepoli, P. Ponikowski, J. Tamargo, M. Tendera, A. Torbicki, W. Wijns, S. Windecker, D. Clement, T. Gillebert, E. Rosei, S. Anker, J. Bauersachs, J. B. Hitij, Mark Caulfield, M. D. De Buyzere, S. D. De Geest, G. Derumeaux, S. Erdine, C. Farsang, C. Funck-Brentano, V. Gerc, G. Germano, S. Gielen, H. Haller, J. Jordan, T. Kahan, M. Komajda, D. Lovic, H. Mahrholdt, Jan Ostergren, G. Parati, J. Perk, J. Polónia, B. Popescu, Ž. Reiner, L. Rydén, Y. Sirenko, A. Stanton, H. Struijker-Boudier, C. Vlachopoulos, M. Volpe, D. Wood   +89 more
semanticscholar   +1 more source

Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications

Advanced Science, EarlyView.
Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee, SeongCheol Jang, Wangmyung Choi, Jaewon Park, Jaehyun Hur, Hocheon Yoo, Hyun‐Suk Kim   +6 more
wiley   +1 more source

Analysis of independent risk factors for high hidden blood loss following total knee arthroplasty. [PDF]

PLoS One
Xu K, Shi W, Guo T, Dong J, Gao T, Jiang Y, Li T.   +6 more
europepmc   +1 more source

Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing

Advanced Science, EarlyView.
Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores, Arianna Bertero, Luca Ceseracciu, Daniel Jiménez‐Boland, Sara Domenici, Mattia Bramini, Paola Sánchez‐Moreno, Erica Scarcelli, Domenico Galdiero, Pavel Fedorov, Daniil Karnaushenko, Rossella Sesia, Ignazio Roppolo, Micaela Pozzati, Mattia Spedicati, Nicolò Petrini, Marco Sangermano, Bartolomeo Coppola, Teresa Gatti   +18 more
wiley   +1 more source

Joint effects of leukocyte-albumin ratio and hypertension are associated with multidimensional cognitive decline and Alzheimer's disease risk in older adults: evidence from NHANES and a clinical AD validation cohort. [PDF]

Front Aging Neurosci
Gao P, Chu Y, Geng M, Tian N, Chen D, Si Y, Liu H, Wang P, Cao J.   +8 more
europepmc   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source