Results 121 to 130 of about 1,525,836 (242)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Maternal and perinatal outcomes associated with prophylactic erythrocytapheresis in pregnant women with sickle cell disease

International Journal of Gynecology &Obstetrics, EarlyView.
Pedro Junqueira Fleury Silva, Giovanna Santos Pinto Coelho, Luana de Jesus Pires, Camila Olivares Figueira, José Paulo de Siqueira Guida, Fernanda G. Surita, Juliana da‐Costa‐Santos, Bruno Deltreggia Benites, Paula de Melo Campos, Simone Cristina Olenscki Gilli, Sara T. O. Saad, Fernando F. Costa, Maria Laura Costa   +12 more
wiley   +1 more source

Rotating Frame Spin‐Lock Cardiac MRI Method at 9.4 T Can Characterize Diffuse Fibrosis in Progressing Hypertensive Heart Disease in Mice

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose This study aimed to investigate the applicability of rotating frame spin‐lock continuous wave (CW) T1ρ and relaxation along a fictitious field with Rank 2 (RAFF2) methods complementary to native T1 and late gadolinium enhancement (LGE) for cardiac magnetic resonance imaging (CMRI) of diffuse fibrosis in mice with advancing hypertensive
Riku Kiviluoto, Diana Törmä, Ahmed Tawfek, Aleksi Leikas, Eetu Räihä, Mari Merentie, Anna‐Kaisa Ruotsalainen, Seppo Ylä‐Herttuala, Elias Ylä‐Herttuala   +8 more
wiley   +1 more source

Noninvasive or minimally invasive neuromodulation in animal models of acute ischemic stroke: A systematic review and meta‐analysis

Neuroprotection, EarlyView.
This systematic review and meta‐analysis assessed the cytoprotective effects of neuromodulation in preclinical models of ischemic stroke. Pooled analyses showed that neuromodulation significantly reduced infarct volume and improved neurological outcomes.
Igor Caitano Salles, Mateus Paquesse Pellegrino, Jessica Borges Kroth, Clara Lucato dos Santos, Luca Schiliro Tristao, Jullyanna Sabrysna Morais Shinosaki, Wanderley Marques Bernardo, Adriana Bastos Conforto   +7 more
wiley   +1 more source

Urgency or emergency – a report on hypertensive crisis with severe retinopathy

Hypertensive crisis is a common condition encountered in primary care clinics. It may result from uncontrolled hypertension or a known cardiovascular risk disease but may also be the first occurrence of undiagnosed secondary hypertension.
Che Yusoff, Mohd Daud, Shalihin, Mohd Shaiful Ehsan   +1 more
core   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Bell's Palsy in 11,255 Cases: Cardiometabolic Associations in a Population‐Based Healthcare Database

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To estimate Bell's palsy incidence and evaluate the prevalence and associations with diabetes and other cardiometabolic conditions. Study Design Population‐based cohort study. Setting Clalit Health Services, the largest healthcare provider organization in Israel (2005‐2022).
Tomer Boldes, Ori Cohen Michael, Ortal Fallek Boldes, Firas Kassem, Benny Nageris, Ameen Biadsee   +5 more
wiley   +1 more source

Promoting positive adolescent sexual health & preventing teenage pregnancy - a review of recent effectiveness research

, 2004
This review was commissioned by the Crisis Pregnancy Agency to inform their work in the area of prevention of crisis pregnancy. The review commences with a brief description of the current epidemiological data on teenage pregnancy and adolescent ...
Fullerton, Deirdre
core  

Preclinical Efficacy and Safety Evaluation of a Novel Controlled‐Expansion ePTFE‐Covered TIPS Stent in a Swine Model

Portal Hypertension &Cirrhosis, EarlyView.
This preclinical study evaluated a novel controlled‐expansion expanded polytetrafluoroethylene (ePTFE)‐covered transjugular intrahepatic portosystemic shunt (TIPS) stent in 11 swine, demonstrating 100% technical success, excellent deployability, and durable 6‐month angiographic patency without thrombosis, migration, fracture, or device‐related toxicity.
Yi Xiang, Qi Zhang, Chuan Liu, Jiawei Zhang, Qingqiao Zhang, Changsheng Shi, Chunze Zhou, Yudong Zhang, Hongliang He, Hao Xie, Hui Shi, Haijian Guo, Wenjing Liu, Muqing Lin, Huajie Yu, Xiaolong Qi   +15 more
wiley   +1 more source

HYPERTENSIVE CRISIS: CLINIC, EMERGENCY CARE

A Hypertensive Crisis Is “An Acute, Pronounced Increase In Blood Pressure, Accompanied By Clinical Symptoms And Requiring An Immediate, Controlled Reduction In Order To Prevent Or Limit Target Organ Damage” [1].
G.T. Mamedova
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