Results 91 to 100 of about 107,047 (281)

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

A Case of Treatment-Resistant Hyperthyroidism: The Need for a Broad Differential Diagnosis

Annals of Internal Medicine: Clinical Cases
Hyperthyroidism is a disease caused by increased production of thyroid hormones that can affect all organ systems within the body. The systemic effects of hyperthyroidism are diverse, ranging from palpitations and anxiety to thyroid storm and cardiogenic
Chitsimran Mann, Gregory Polcha
doaj   +1 more source

Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene [PDF]

, 2020
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatosis initially described as ‘comedo nevus’ and renamed ‘PEODDN’; it has also been referred to as linear eccrine nevus with comedones, porokeratotic eccrine ostial and hair ...
Alomran, Husain, Kanitakis, Jean
core  

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium-Phosphate Homeostasis in Healthy Older Cats [PDF]

, 2016
Background Dietary phosphate and protein restriction decreases plasma PTH and FGF‐23 concentrations and improves survival time in azotemic cats, but has not been examined in cats that are not azotemic.
Antoniucci, Backlund, Barber, Barber, Berndt, Brown, Burnett, Dong, Elliott, Ferrari, Finch, Finch, Finch, Freeman, Geddes, Geddes, Greene, Hall, Hoek, Hutchins-Wiese, Isakova, Isakova, Isakova, Jepson, Jepson, Jepson, Jepson, Kamycheva, Kumar, Laflamme, Larsson, Lulich, Marino, Moe, Muntner, Nishida, NRC, Paepe, Parker, Pineda, Reynolds, Ross, Saito, Schulz, Shipov, Sigrist, Spatz, Trivedi, Wakeling, Wakeling, Williams, Zhang   +51 more
core   +3 more sources

The Dynamic Evolution of Lipid Profiles Following Transjugular Intrahepatic Portosystemic Shunt in Patients With Liver Cirrhosis

Portal Hypertension &Cirrhosis, EarlyView.
Cirrhosis is frequently accompanied by varying degrees of lipid profile abnormalities. This study confirms that these profiles are differentially affected by disease etiology and progressively worsen—with significant reductions in TC, HDL‐C, and LDL‐C—as liver disease severity increases. TIPS improves lipid profiles, particularly by increasing HDL‐C in
Jiamin Xu, Qinnian Li, Lagan Kumar Manandhar, Bilian Zhu, Chenrui Zhang, Weimin Bao, Yingmei Tang   +6 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study.

PLoS ONE, 2013
AimsTo examine the long-term risk of hyperthyroidism in patients admitted to hospital with new-onset AF. Hyperthyroidism is a well-known risk factor for atrial fibrillation (AF), but it is unknown whether new-onset AF predicts later-occurring ...
Christian Selmer, Morten Lock Hansen, Jonas Bjerring Olesen, Charlotte Mérie, Jesper Lindhardsen, Anne-Marie Schjerning Olsen, Jesper Clausager Madsen, Ulla Schmidt, Jens Faber, Peter Riis Hansen, Ole Dyg Pedersen, Christian Torp-Pedersen, Gunnar Hilmar Gislason   +12 more
doaj   +1 more source

Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report [PDF]

, 2017
There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine.
Benvenga, S, Centanni, Marco, Sachmechi, I.   +2 more
core   +1 more source

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

Phytotherapy Research, EarlyView.
ABSTRACT Over the last decade, ashwagandha (Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler, R. Al‐Mondhiry, L. Lang, R. Marles, M. Tallon, A. Raghu   +5 more
wiley   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S., Dutton, Charyl M., Heufelder, Armin E., Sarkar, Gobinda   +3 more
core   +1 more source