Results 201 to 210 of about 123,987 (295)

Different eGFR markers and prediction of cardiovascular risk

open access: yesJournal of Internal Medicine, Volume 299, Issue 1, Page 143-157, January 2026.
Abstract Background Renal dysfunction increases cardiovascular (CV) risk. We compared cystatin C‐based estimated glomerular filtration rate (eGFRcys), creatinine‐based eGFR (eGFRcr), and their ratio (eGFRcys/eGFRcr) in relation to major adverse cardiovascular events (MACE) and all‐cause mortality in chronic coronary syndrome, assessing the added ...
Maria Tydén   +9 more
wiley   +1 more source

Changes of carbohydrate metabolism in disorders of thyroid function [PDF]

open access: yes, 1970
Bottermann, P.   +4 more
core  

Fuzuloparib with or without apatinib as maintenance therapy in newly diagnosed, advanced ovarian cancer (FZOCUS‐1): A multicenter, randomized, double‐blind, placebo‐controlled phase 3 trial

open access: yesCA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Abstract Although poly(adenosine diphosphate‐ribose) polymerase inhibitors (PARPis) and bevacizumab were approved as first‐line maintenance for advanced ovarian cancer (OC), evidence comparing this combination with PARPi monotherapy, especially in BRCA‐mutated/homologous recombination‐deficient (HRD) patients, is lacking.
Lingying Wu   +56 more
wiley   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

open access: yesAdvanced Science, Volume 12, Issue 45, December 4, 2025.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng   +14 more
wiley   +1 more source

Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis

open access: yesBrain and Behavior, Volume 15, Issue 12, December 2025.
This graphical abstract summarizes a multi‐layered analytical framework integrating cis‐eQTLs, UKB‐PPP proteomics, and multivariable Mendelian randomization to dissect the causal links between circulating proteins, vascular risk factors, ischemic stroke (IS), and vascular dementia (VD).
Jian Lyu   +9 more
wiley   +1 more source

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