Results 1 to 10 of about 321,589 (402)

Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes

Nature Communications, 2021
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or proteomic features in involved tissues that define pathobiological differences between patients.
Bradley A. Maron, Rui-Sheng Wang, Sergei Shevtsov, Stavros G. Drakos, Elena Arons, Omar Wever-Pinzon, Gordon S. Huggins, Andriy O. Samokhin, William M. Oldham, Yasmine Aguib, Magdi H. Yacoub, Ethan J. Rowin, Barry J. Maron, Martin S. Maron, Joseph Loscalzo   +14 more
doaj   +2 more sources

Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We report characteristics and outcomes of elderly patients with hypertrophic cardiomyopathy (HCM) with basal septal hypertrophy and dynamic left ventricular outflow tract obstruction.
Alaa Alashi, Nicholas G. Smedira, Zoran B. Popovic, Agostina Fava, Maran Thamilarasan, Samir R. Kapadia, Per Wierup, Harry M. Lever, Milind Y. Desai   +8 more
doaj   +1 more source

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

Nature Network Boston, 2023
Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart failure and sudden cardiac death.
D. Reichart, Gregory A. Newby, H. Wakimoto, M. Lun, J. Gorham, Justin J. Curran, Aditya Raguram, D. DeLaughter, D. Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, D. Page, N. Zabaleta, L. Vandenberghe, David R. Liu, J. Seidman, C. Seidman   +17 more
semanticscholar   +1 more source

Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Hypertrophic cardiomyopathy (HCM) and aortic stenosis can cause obstruction to the flow of blood out of the left ventricular outflow tract into the aorta, with obstructive HCM resulting in dynamic left ventricular outflow tract obstruction and
Milind Y. Desai, Alaa Alashi, Zoran B. Popovic, Per Wierup, Brian P. Griffin, Maran Thamilarasan, Douglas Johnston, Lars G. Svensson, Harry M. Lever, Nicholas G. Smedira   +9 more
doaj   +1 more source

Mavacamten: a first-in-class myosin inhibitor for obstructive hypertrophic cardiomyopathy

European Heart Journal, 2023
Graphical Abstract Graphical Abstract The path to treatment of obstructive hypertrophic cardiomyopathy. (Top left) Haemodynamic observations demonstrated. Left ventricular (LV) obstruction and symptoms related to LV hypertrophy.
E. Braunwald, S. Saberi, T. Abraham, Perry M. Elliott, I. Olivotto   +4 more
semanticscholar   +1 more source

Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background In patients with obstructive hypertrophic cardiomyopathy, surgical myectomy (SM) is indicated for severe symptoms. We sought to compare long‐term outcomes of patients with obstructive hypertrophic cardiomyopathy where SM was based on guideline‐
Alaa Alashi, Nicholas G. Smedira, Kevin Hodges, Zoran B. Popovic, Maran Thamilarasan, Per Wierup, Harry M. Lever, Milind Y. Desai   +7 more
doaj   +1 more source

Predictors of cardiac involvement and survival in patients with primary systemic light-chain amyloidosis: roles of the clinical, chemical, and 3-D speckle tracking echocardiography parameters

BMC Cardiovascular Disorders, 2021
Background Light-chain (AL) amyloidosis is the most common type of systemic amyloidosis with poor prognosis. Currently, the predictors of cardiac involvement and prognostic staging systems are primarily based on conventional echocardiography and ...
Changhui Lei, Xiaoli Zhu, David H. Hsi, Jing Wang, Lei Zuo, Shengjun Ta, Qianli Yang, Lei Xu, Xueli Zhao, Yan Wang, Shiren Sun, Liwen Liu   +11 more
doaj   +1 more source

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations
Sara Ranjbarvaziri, Kristina B. Kooiker, M. Ellenberger, G. Fajardo, Mingming Zhao, A. V. Vander Roest, R. A. Woldeyes, Tiffany T Koyano, R. Fong, Ning Ma, Lei Tian, G. Traber, F. Chan, J. Perrino, Sushma Reddy, Wah Chiu, Joseph C. Wu, Joseph Y. Woo, K. Ruppel, J. Spudich, M. Snyder, K. Contrepois, D. Bernstein   +22 more
semanticscholar   +1 more source

Clinical characteristics and outcomes in childhood-onset hypertrophic cardiomyopathy

European Heart Journal, 2021
Aims Childhood-onset hypertrophic cardiomyopathy (HCM) is far less common than adult-onset disease, thus natural history is not well characterized. We aim to describe the characteristics and outcomes of childhood-onset HCM.
N. Marston, Larry Han, I. Olivotto, S. Day, E. Ashley, M. Michels, A. Pereira, J. Ingles, C. Semsarian, D. Jacoby, S. Colan, J. Rossano, S. Wittekind, J. Ware, S. Saberi, A. Helms, Carolyn Y. Ho   +16 more
semanticscholar   +1 more source

Perioperative Amiodarone to Prevent Atrial fibrillation after Septal Myectomy in obstrUctive hypeRtroPHic cardiomyopathy

ESC Heart Failure, 2021
Aims Amiodarone reduces the incidence of atrial fibrillation (AF) following coronary artery bypass surgery; however, the benefit of perioperative amiodarone in patients undergoing septal myectomy (SM) for obstructive hypertrophic cardiomyopathy (oHCM ...
Evan F. Shalen, Stephen B. Heitner, Lana Al‐Rashdan, Reyhaneh Akhavein, Miriam R. Elman, Katherine L. Fischer, Lucy Q. Lin, Meghan Mannello, Babak Nazer, Howard K. Song, Ahmad Masri   +10 more
doaj   +1 more source