Results 11 to 20 of about 282,907 (338)

Trans-Septal Myocardial Biopsy in Hypertrophic Cardiomyopathy Using the Liwen Procedure: An Introduction of a Novel Technique [PDF]

Journal of Interventional Cardiology, 2021
Objective. The purpose of this study was to evaluate the feasibility and safety of myocardial biopsy using a new approach, the Liwen procedure. Background.
Chao Han, Mengyao Zhou, Rui Hu, Bo Wang, Lei Zuo, Jing Li, Shengjun Ta, David H. Hsi, Jiani Liu, Lichun Wei, Liwen Liu   +10 more
doaj   +2 more sources

Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes

Nature Communications, 2021
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or proteomic features in involved tissues that define pathobiological differences between patients.
Bradley A. Maron, Rui-Sheng Wang, Sergei Shevtsov, Stavros G. Drakos, Elena Arons, Omar Wever-Pinzon, Gordon S. Huggins, Andriy O. Samokhin, William M. Oldham, Yasmine Aguib, Magdi H. Yacoub, Ethan J. Rowin, Barry J. Maron, Martin S. Maron, Joseph Loscalzo   +14 more
doaj   +2 more sources

Isolated Right Ventricular Hypertrophic Cardiomyopathy Mimicking an Intramural Mass in a 13‐Year‐Old Male [PDF]

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Hypertrophic cardiomyopathy (HCM) primarily involves the left ventricle, with severe right ventricular hypertrophy or right ventricular outflow tract (RVOT) obstruction being rare. Hypertrophic myocardium may mimic intramural masses, requiring imaging, intraoperative observation and pathological examination for diagnosis.
Hu Tingting, Ma Guotao, Li Xiaona, Shi Ximin, Liu Yongtai   +4 more
wiley   +2 more sources

Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We report characteristics and outcomes of elderly patients with hypertrophic cardiomyopathy (HCM) with basal septal hypertrophy and dynamic left ventricular outflow tract obstruction.
Alaa Alashi, Nicholas G. Smedira, Zoran B. Popovic, Agostina Fava, Maran Thamilarasan, Samir R. Kapadia, Per Wierup, Harry M. Lever, Milind Y. Desai   +8 more
doaj   +1 more source

Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background In patients with obstructive hypertrophic cardiomyopathy, surgical myectomy (SM) is indicated for severe symptoms. We sought to compare long‐term outcomes of patients with obstructive hypertrophic cardiomyopathy where SM was based on guideline‐
Alaa Alashi, Nicholas G. Smedira, Kevin Hodges, Zoran B. Popovic, Maran Thamilarasan, Per Wierup, Harry M. Lever, Milind Y. Desai   +7 more
doaj   +1 more source

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

Nature Medicine, 2023
Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart failure and sudden cardiac death.
D. Reichart, Gregory A. Newby, H. Wakimoto, M. Lun, J. Gorham, Justin J. Curran, Aditya Raguram, D. DeLaughter, D. Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, D. Page, N. Zabaleta, L. Vandenberghe, David R. Liu, J. Seidman, C. Seidman   +17 more
semanticscholar   +1 more source

Mavacamten: a first-in-class myosin inhibitor for obstructive hypertrophic cardiomyopathy

European Heart Journal, 2023
Graphical Abstract Graphical Abstract The path to treatment of obstructive hypertrophic cardiomyopathy. (Top left) Haemodynamic observations demonstrated. Left ventricular (LV) obstruction and symptoms related to LV hypertrophy.
E. Braunwald, S. Saberi, T. Abraham, Perry M. Elliott, I. Olivotto   +4 more
semanticscholar   +1 more source

Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Hypertrophic cardiomyopathy (HCM) and aortic stenosis can cause obstruction to the flow of blood out of the left ventricular outflow tract into the aorta, with obstructive HCM resulting in dynamic left ventricular outflow tract obstruction and
Milind Y. Desai, Alaa Alashi, Zoran B. Popovic, Per Wierup, Brian P. Griffin, Maran Thamilarasan, Douglas Johnston, Lars G. Svensson, Harry M. Lever, Nicholas G. Smedira   +9 more
doaj   +1 more source

Effect of Mavacamten on Chinese Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy

JAMA cardiology, 2023
Key Points Question What is the effect of treatment with mavacamten on Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy? Findings In this phase 3 randomized clinical trial of 81 patients, mavacamten significantly improved ...
Z. Tian, Liwen Li, Xiaoyan Li, Jian’an Wang, Qing Zhang, Zhan-hui Li, Daoquan Peng, Ping‐Ping Yang, Wei Ma, Fang-Ming Wang, Wei Jin, Xiang Cheng, Jing Sun, Yiqun Fu, Chengjian Lyu, Shuyang Zhang   +15 more
semanticscholar   +1 more source

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations
Sara Ranjbarvaziri, K. Kooiker, M. Ellenberger, G. Fajardo, Mingming Zhao, A. V. Vander Roest, R. A. Woldeyes, Tiffany T Koyano, R. Fong, Ning Ma, Lei Tian, G. Traber, F. Chan, J. Perrino, Sushma Reddy, Wah Chiu, Joseph C. Wu, Joseph Y. Woo, K. Ruppel, J. Spudich, M. Snyder, K. Contrepois, D. Bernstein   +22 more
semanticscholar   +1 more source