Results 101 to 110 of about 674,192 (414)

Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement

open access: yesFrontiers in Physiology, 2022
The urinary bladder is markedly enlarged in the type 1 diabetes mellitus model of streptozotocin-injected rats, which may contribute to the frequent diabetic uropathy. Much less data exists for models of type 2 diabetes.
Zeynep E. Yesilyurt   +15 more
doaj   +1 more source

Three-dimensional Cardiovascular Imaging-Genetics: A Mass Univariate Framework [PDF]

open access: yes, 2017
MOTIVATION: Left ventricular (LV) hypertrophy is a strong predictor of cardiovascular outcomes, but its genetic regulation remains largely unexplained. Conventional phenotyping relies on manual calculation of LV mass and wall thickness, but advanced cardiac image analysis presents an opportunity for high-throughput mapping of genotype-phenotype ...
arxiv   +1 more source

Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium [PDF]

open access: yes, 2010
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training.
Adams   +98 more
core   +1 more source

Basal Septal Hypertrophy [PDF]

open access: yesCurrent Cardiology Reviews, 2014
A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background
Jamil Mayet   +3 more
openaire   +3 more sources

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

open access: yesNature Communications, 2018
AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ...
R. Gélinas   +20 more
semanticscholar   +1 more source

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

open access: yesAdvanced Science, EarlyView.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du   +7 more
wiley   +1 more source

Come together over me: Cells that form the dermatocranium and chondrocranium in mice

open access: yesThe Anatomical Record, EarlyView., 2023
Abstract Most bone develops either by intramembranous ossification where bone forms within a soft connective tissue, or by endochondral ossification by way of a cartilage anlagen or model. Bones of the skull can form endochondrally or intramembranously or represent a combination of the two types of ossification.
M. Kathleen Pitirri   +5 more
wiley   +1 more source

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States

open access: yesCell Reports, 2020
Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators.
Tanner Stokes   +13 more
doaj  

SCUNet++: Swin-UNet and CNN Bottleneck Hybrid Architecture with Multi-Fusion Dense Skip Connection for Pulmonary Embolism CT Image Segmentation [PDF]

open access: yesWACV 2024, 2023
Pulmonary embolism (PE) is a prevalent lung disease that can lead to right ventricular hypertrophy and failure in severe cases, ranking second in severity only to myocardial infarction and sudden death. Pulmonary artery CT angiography (CTPA) is a widely used diagnostic method for PE. However, PE detection presents challenges in clinical practice due to
arxiv  

Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training [PDF]

open access: yes, 2008
Purpose of Review: Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging.
Cribb, Paul J, Hayes, Alan
core   +1 more source

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