Results 81 to 90 of about 528,761 (298)

3D‐Printed Gastrointestinal Stents: In Vivo Evaluation in a Swine Small Bowel Perforation Model

Advanced Healthcare Materials, EarlyView.
Gastrointestinal fistulae and perforations can lead to severe complications including sepsis and patient death. In this work, the efficacy of 3D‐printed gastrointestinal stents composed of poly‐lactic‐acid (PLA) was evaluated in an in vivo swine model.
Gweniviere Capron, Parinaz Fathi, Tor Wolf Jensen, Derek J. Milner, André J. van der Vlies, Regan L. Moody, Elizabeth A. Bangert, Blair Rowitz, Dipanjan Pan, Matthew B. Wheeler   +9 more
wiley   +1 more source

Circ_0001052 promotes cardiac hypertrophy via elevating Hipk3 [PDF]

, 2023
Mengyue Yang, Weichen Wang, Longlong Wang, Yuze Li   +3 more
openalex   +1 more source

Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury

Nature Communications, 2018
Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division.
E. Lazzeri, M. Angelotti, A. Peired, C. Conte, J. Marschner, L. Maggi, B. Mazzinghi, D. Lombardi, M. Melica, Sara Nardi, E. Ronconi, Alessandro Sisti, Giulia Antonelli, F. Becherucci, L. De Chiara, Ricardo Romero Guevara, Alexa Burger, B. Schaefer, F. Annunziato, H. Anders, L. Lasagni, P. Romagnani   +21 more
semanticscholar   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential

Nature Reviews Cardiology, 2023
Thomas G. Martin, Miranda A. Juarros, L. Leinwand   +2 more
semanticscholar   +1 more source

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test

Italian Journal of Animal Science
Among the Italian autochthonous beef cattle breeds, Marchigiana is particularly important in terms of census and production. In this breed, a SNP inactivating the myostatin gene leads to muscular hypertrophy in the individuals homozygous for the mutated ...
Daniele Colombi, Francesco Perini, Fiorella Sbarra, Andrea Quaglia, Lakamy Sylla, Maria Gracia Luigi-Sierra, Marcel Amills, Emiliano Lasagna   +7 more
doaj   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

JCI Insight, 2019
The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target of rapamycin-mediated (mTOR-mediated) podocyte hypertrophy is recognized as an important ...
Victor G. Puelles, J. W. van der Wolde, Nicola Wanner, M. Scheppach, L. Cullen-McEwen, Tillmann Bork, M. Lindenmeyer, Lukas Gernhold, M. N. Wong, Fabian Braun, C. Cohen, M. Kett, C. Kuppe, R. Kramann, Turgay Saritas, C. V. van Roeyen, M. Moeller, L. Tribolet, R. Rebello, Y. B. Sun, Jinhua Li, G. Müller-Newen, M. Hughson, W. Hoy, F. Person, T. Wiech, S. Ricardo, P. Kerr, K. Denton, L. Furic, T. Huber, D. Nikolic-Paterson, J. Bertram   +32 more
semanticscholar   +1 more source