Results 81 to 90 of about 760,497 (383)

Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease

Biomedicines
There is ample evidence on the benefit of angiotensin receptor-neprilysin inhibitors (ARNIs) in heart failure, yet data regarding the potential protective action of ARNIs in hypertensive heart disease are sparse. The aim of this study was to show whether
Peter Stanko, Kristina Repova, Tomas Baka, Kristina Krajcirovicova, Silvia Aziriova, Andrej Barta, Stefan Zorad, Michaela Adamcova, Fedor Simko   +8 more
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, EarlyView.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source

Unlocking Potential: Low Bovine Serum Albumin Enhances the Chondrogenicity of Human Adipose-Derived Stromal Cells in Pellet Cultures

Biomolecules
Bovine serum albumin (BSA) plays a crucial role in cell culture media, influencing cellular processes such as proliferation and differentiation. Although it is commonly included in chondrogenic differentiation media, its specific function remains unclear.
Isabel Casado-Losada, Melanie Acosta, Barbara Schädl, Eleni Priglinger, Susanne Wolbank, Sylvia Nürnberger   +5 more
doaj   +1 more source

Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy

Cells, 2020
Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, Patrice Delafontaine
doaj   +1 more source

The SRSF4–GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy [PDF]

, 2021
Javier Larrasa-Alonso, María Villalba‐Orero, Carlos Martí‐Gómez, Paula Ortiz-Sánchez, Marina López‐Olañeta, M. Ascensión Rey-Martín, Fátima Sánchez‐Cabo, François McNicoll, Michaela Müller-McNicoll, Pablo García‐Pavía, Enrique Lara‐Pezzi   +10 more
openalex   +1 more source

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

Nature Communications, 2018
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct cardiomyocyte gene programs encoding ...
S. Nomura, M. Satoh, T. Fujita, Tomoaki Higo, Tomokazu S. Sumida, T. Ko, Toshihiro Yamaguchi, Takashige Tobita, A. Naito, Masamichi Ito, K. Fujita, M. Harada, H. Toko, Yoshio Kobayashi, K. Ito, E. Takimoto, H. Akazawa, H. Morita, H. Aburatani, I. Komuro   +19 more
semanticscholar   +1 more source

Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training [PDF]

, 2008
Purpose of Review: Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging.
Cribb, Paul J, Hayes, Alan
core   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Abnormalities in lysine degradation are involved in early cardiomyocyte hypertrophy development in pressure-overloaded rats [PDF]

, 2021
Jialing Liu, Junhao Hu, Lanlan Tan, Qi Zhou, Xiaojing Wu   +4 more
openalex   +1 more source