Results 51 to 60 of about 30,173 (242)

GENETICS IN ENDOCRINOLOGY: Genetic counseling for congenital hypogonadotropic hypogonadism and Kallmann syndrome: new challenges in the era of oligogenism and next-generation sequencing.

European Journal of Endocrinology, 2018
Congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) are rare, related diseases that prevent normal pubertal development and cause infertility in affected men and women. However, the infertility carries a good prognosis as increasing
L. Maione, A. Dwyer, B. Francou, A. Guiochon‐Mantel, N. Binart, J. Bouligand, Jacques Young   +6 more
semanticscholar   +1 more source

Hypogonadotropic Hypogonadism Associated with Hereditary Hemorrhagic Telengiectasia

Case Reports in Endocrinology, 2013
A 65-year-old man was referred to our clinic for the rehabilitation of right hemiparesis caused by ischaemic stroke. Hypertension, postphlebitic syndrome of lower limbs, frequent nose bleeding, and anemia were present in his history; in his adolescence ...
Scarano Valentina, De Santis Daniele, Suppressa Patrizia, Lastella Patrizia, Lenato Gennaro Mariano, Triggiani Vincenzo, Sabbà Carlo   +6 more
doaj   +1 more source

Hypogonadotropic Hypogonadism Associated With Obesity: A Case Report

Case Reports in Clinical Practice, 2021
One of the critical factors with a broad impact on health is obesity. Besides its cardiovascular comorbidities, obesity’s probable association with hypogonadotropic hypogonadism in men will be discussed in this article by reporting a severely obese boy ...
Niloufar Johari Varnoosfaderani, Sahar Karimpour Reihan, Mahsa Abbaszadeh, Nasim Khajavirad   +3 more
doaj   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

eLife, 2019
Congenital hypogonadotropic hypogonadism (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing hormone (GnRH) deficiency, which is often associated with anosmia (Kallmann syndrome, KS).
S. Malone, Georgios E. Papadakis, A. Messina, N. Mimouni, S. Trova, M. Imbernón, C. Allet, I. Cimino, J. Acierno, Daniele Cassatella, Cheng Xu, R. Quinton, G. Szinnai, P. Pigny, Lur Alonso-Cotchico, Laura Masgrau, Jean‐Didier Maréchal, V. Prévot, N. Pitteloud, P. Giacobini   +19 more
semanticscholar   +1 more source

A Rare Presentation of Transfusional Hemochromatosis: Hypogonadotropic Hypogonadism

Case Reports in Endocrinology, 2015
Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction. β-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for ...
Rifki Ucler, Erdal Kara, Murat Atmaca, Sehmus Olmez, Murat Alay, Yaren Dirik, Aydin Bora   +6 more
doaj   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

RNF216 Regulates the Migration of Immortalized GnRH Neurons by Suppressing Beclin1-Mediated Autophagy

Frontiers in Endocrinology, 2019
RNF216, encoding an E3 ubiquitin ligase, has been identified as a causative gene for Gordon Holmes syndrome, characterized by ataxia, dementia, and hypogonadotropic hypogonadism.
Fangfang Li, Fangfang Li, Dengfeng Li, Dengfeng Li, Huadie Liu, Huadie Liu, Bei-Bei Cao, Bei-Bei Cao, Fang Jiang, Fang Jiang, Dan-Na Chen, Jia-Da Li, Jia-Da Li   +12 more
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Hypogonadotropic hypogonadism in men with hereditary hemochromatosis [PDF]

Basic and Clinical Andrology, 2017
Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to
Jacques Hubert, Rabih El Osta, Isabelle Koscinski, Nicolas Grandpre, Nicolas Monnin   +4 more
openaire   +4 more sources