Results 81 to 90 of about 41,302 (312)

Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism [PDF]

, 2022
Àngela Vidal, Carolin Dhakal
openalex   +1 more source

Hypogonadotropic Hypogonadism in Men With Diabesity

Diabetes Care, 2018
One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty.
S. Dhindsa, H. Ghanim, M. Batra, P. Dandona   +3 more
semanticscholar   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

TBX3‐ Related Disorder

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 291-299, February 2026.
ABSTRACT Heterozygous pathogenic variants in TBX3 cause Ulnar‐Mammary syndrome (UMS). The phenotype is classically characterized by upper limb defects, apocrine/mammary gland hypoplasia, hypogonadism, and various midline defects. However, the clinical spectrum is highly variable, and some individuals may present with a mild or atypical presentation ...
Ziv Halperin, Karin Weiss
wiley   +1 more source

Pineal germinoma – hypogonadism issues [PDF]

Archives of the Balkan Medical Union, 2019
Introduction. Pineal tumors are an inhomogeneous group of lesions with pineal origin, characterized by various degrees of hypothalamic-pituitary dysfunction. Case presentation.
Alexandra BOLOCAN, Bogdan SOCEA, Dan N. PADURARU, Oana BOTEZAN, Octavian ANDRONIC, Andra MORAR, Cristina MOLDOVAN, Alexandra ENE, Roxana TURTUREA, Mara CARSOTE, Ana VALEA   +10 more
doaj   +1 more source

Hypogonadotropic Hypogonadism Associated With Obesity: A Case Report

Case Reports in Clinical Practice, 2021
One of the critical factors with a broad impact on health is obesity. Besides its cardiovascular comorbidities, obesity’s probable association with hypogonadotropic hypogonadism in men will be discussed in this article by reporting a severely obese boy ...
Niloufar Johari Varnoosfaderani, Sahar Karimpour Reihan, Mahsa Abbaszadeh, Nasim Khajavirad   +3 more
doaj   +1 more source

DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease. [PDF]

, 2015
DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita.
Achermann, JC, Buonocore, F, Duncan, AJ, Suntharalingham, JP   +3 more
core   +1 more source

Evidence for a Common Genetic Origin of Classic and Milder Adult-Onset Forms of Isolated Hypogonadotropic Hypogonadism

Journal of Clinical Medicine, 2019
Multiple metabolic and inflammatory mechanisms are considered the determinants of acquired functional isolated hypogonadotropic hypogonadism (IHH) in males, whereas classic IHH is a rare congenital condition with a strong genetic background.
B. Cangiano, P. Duminuco, V. Vezzoli, F. Guizzardi, I. Chiodini, G. Corona, M. Maggi, L. Persani, M. Bonomi   +8 more
semanticscholar   +1 more source

Gonadal function in males with WFS1 spectrum disorder (Wolfram syndrome)—A European cohort perspective

Andrology, Volume 14, Issue 2, Page 398-410, February 2026.
Abstract Background WFS1 spectrum disorder, also known as Wolfram syndrome (WS) is an ultra‐rare (<1:500,000; ORPHA: 3463) monogenic (OMIM #222300) progressive neuroendocrine and neurodegenerative disorder, characterised by early‐onset insulin‐dependent diabetes, optic atrophy, central diabetes insipidus and sensi‐neuronal deafness.
Julia Rohayem, Olivia Cunningham, Denise Williams, Joachim Wistuba, Liam McCarthy, Timothy G. Barrett, Renuka P. Dias   +6 more
wiley   +1 more source

Case report: Novel SIN3A loss-of-function variant as causative for hypogonadotropic hypogonadism in Witteveen–Kolk syndrome

Frontiers in Genetics
Pubertal delay can be due to hypogonadotropic hypogonadism (HH), which may occur in association with anosmia or hyposmia and is known as Kallmann syndrome (OMIM #308700).
Lourdes Correa Brito, Ana Keselman, Florencia Villegas, Paula Scaglia, Paula Scaglia, María Esnaola Azcoiti, María Esnaola Azcoiti, Sebastián Castro, Nora Sanguineti, Agustín Izquierdo, Agustín Izquierdo, Marianela Maier, Ignacio Bergadá, Claudia Arberas, Rodolfo A. Rey, Rodolfo A. Rey, Rodolfo A. Rey, María Gabriela Ropelato, María Gabriela Ropelato   +18 more
doaj   +1 more source