Results 21 to 30 of about 2,841 (212)

Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation. [PDF]

, 2014
The TNF family ligand ectodysplasin A (EDA) regulates the induction, morphogenesis and/or maintenance of skin-derived structures such as teeth, hair, sweat glands and several other glands.
Kowalczyk-Quintas, C., Schneider, P.
core   +1 more source

Ectodermal dysplasia: Report of two cases in a family and literature review

Journal of Family Medicine and Primary Care, 2019
Ectodermal dysplasia (ED) is a inherited genetic disorder with manifestations of abnormalities in more than one ectodermal derivatives like skin, hair, nails, exocrine glands and teeth.
Vani Chappidi, Dheeraj Voulligonda, Bharadwaj Bhogavaram, P Krishnanjaneya Reddy   +3 more
doaj   +1 more source

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants

Nature Communications, 2023
EDA variants are associated with X-linked hypohidrotic dysplasia. Here, the authors report the crystal structure of the human EDA-EDAR complex, reveal the important role of this complex in ectodermal development and uncover the structural mechanism of ...
Kang Yu, Chenhui Huang, Futang Wan, Cailing Jiang, Juan Chen, Xiuping Li, Feng Wang, Jian Wu, Ming Lei, Yiqun Wu   +9 more
doaj   +1 more source

Early prosthodontic intervention in a child patient of hypohidrotic ectodermal dysplasia

SRM Journal of Research in Dental Sciences, 2013
The ectodermal dysplasias (EDs) comprise a large, heterogeneous group of inherited disorders that are defined by primary defects in the development of two or more tissues derived from embryonic ectoderm.
Culatur Thulasingam, Meenakshi Akshayalingam, Pallavi Vashisht   +2 more
doaj   +1 more source

mutation in autosomal dominant hypohidrotic ectodermal dysplasia in two Swedish families [PDF]

, 2006
BACKGROUND: Hypohidrotic ectodermal dysplasia (HED) is a genetic disorder characterized by defective development of teeth, hair, nails and eccrine sweat glands.
Lejon, Kristina, Lind, Lisbet K, Schmitt-Egenolf, Marcus, Stecksén-Blicks, Christina   +3 more
core   +3 more sources

Hypohidrotic ectodermal dysplasia and finger clubbing – An unknown association

Asian Journal of Medical Sciences, 2014
The ectodermal dysplasias are heterogenous group of inherited disorders with primary defects in tissues derived from embryonic ectoderm such as hair, tooth, nail and sweat gland.
Amit Sarkar
doaj   +1 more source

First report of X-linked hypohidrotic ectodermal dysplasia with a hemizygous c.1142G > C in the EDA gene: variant of uncertain significance or new pathogenic variant?

Italian Journal of Pediatrics, 2021
Background Hypohidrotic Ectodermal Dysplasia (HED) is a genetic disorder which affects structures of ectodermal origin. X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of disease.
Mario Tumminello, Antonella Gangemi, Federico Matina, Melania Guardino, Bianca Lea Giuffrè, Giovanni Corsello   +5 more
doaj   +1 more source

Rehabilitation of ectodermal dysplasia patient with a telescopic denture in the maxilla and mandibular implant assisted overdenture: A case report

Clinical Case Reports, 2021
Hypohidrotic ectodermal dysplasia is a heritable disease, characterized by hypodontia, hypotrichosis, and anhidrosis. This clinical report demonstrates prosthetic rehabilitation of a patient complaining of impaired mastication and the odd appearance of ...
Heba Alajami, Jamal Saker
doaj   +1 more source

Oligodontia Management in a Resource-Limited Setting: Two Case Reports and Review of Literature. [PDF]

Case Rep Dent
Introduction: Oligodontia represents the developmental absence of six or more teeth, posing significant challenges for masticatory function, speech, and psychosocial well‐being. While extensively documented in developed countries, limited reports exist from resource‐constrained settings in Africa.
Malami AB, Ogbozor BE, Okolo CC, Aborisade AO, Mahmud UB, Abulfathi AA, Adeyemo YI.   +6 more
europepmc   +2 more sources

Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia. [PDF]

, 2014
Development of ectodermal appendages, such as hair, teeth, sweat glands, sebaceous glands, and mammary glands, requires the action of the TNF family ligand ectodysplasin A (EDA).
Dang, A.T., Donzé, O., Gaide, O., Headon, D.J., Hermes, K., Kirby, N., Kowalczyk-Quintas, C., Sarrasin, H., Schneider, H., Schneider, P., Tardivel, A., Willen, L.   +11 more
core   +1 more source