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Thyrotoxic hypokalemic periodic paralysis [PDF]

QJM - Monthly Journal of the Association of Physicians, 2018
Hypokalemia is a serious and life-threatening clinical condition. We present a case of a 45-year-old male, with known hyperthyroidism presenting with profound tremor, irritability, quadriparesis, and labored breathing since morning, on the day of admission. Arterial blood gas analysis showed severe hypokalemia.
Hernández J L, J L Hernández
exaly   +5 more sources

Hypokalemic Periodic Paralysis in a Young Woman With Mast Cell Activation Syndrome: A Case Report of an Atypical Presentation Associated With an Ultra-Rare CACNA1S Variant. [PDF]

Clin Case Rep
ABSTRACT Hypokalemic periodic paralysis (hKPP) is a rare neuromuscular channelopathy characterized by transient episodes of muscle weakness or paralysis associated with low serum potassium levels. It has been most commonly linked to autosomal dominant mutations in ion channel genes, specifically CACNA1S and SCN4A, which impair skeletal muscle ...
Moradi A, Aboutaleb Y, Noreen S, Sahyouni A, Sharma H, Oyesanmi O, Kahane IM, Lin Y, Toka HR.   +8 more
europepmc   +2 more sources

Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
ABSTRACT Introduction/Aims Hypokalemic periodic paralysis (HypoKPP) is an ion channelopathy causing episodic skeletal muscle weakness triggered by hypokalemia. Reduced inward rectifier K+ (Kir) channel activity contributes to membrane depolarization and paralysis, suggesting that pharmacologic activation of muscle K+ channels may restore excitability ...
Denman K, Rich MM.
europepmc   +2 more sources

Efficacy of a K⁺ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
Pretreatment with an agonist of Kv7 potassium channels (XEN1101) protects the soleus muscle from a loss of force during a 2 mM K+ challenge, in a mouse model of hypokalemic periodic paralysis. ABSTRACT Introduction/Aims Effective management remains lacking for recurrent episodes of acute weakness in hypokalemic periodic paralysis (HypoPP).
Chanchykov V, Iype S, Quinonez M, Wu F, Cannon S.   +4 more
europepmc   +2 more sources

Hypokalemic Periodic Paralysis Associated With a Rare <i>CACNA1S</i> Variant (p.Leu1243Val): Expanding the Mutational Spectrum. [PDF]

Case Rep Genet
Background Hypokalemic periodic paralysis (HypoPP) is a rare skeletal muscle channelopathy, most often caused by mutations in CACNA1S or SCN4A. Most pathogenic CACNA1S mutations affect arginine residues in S4 voltage‐sensor domains, but other variants remain poorly understood.
Nader MA.
europepmc   +2 more sources

Hyperthyroid Hypokalemic Periodic Paralysis in a Nepali Male; A Case Report. [PDF]

Clin Case Rep
ABSTRACT Hyperthyroid Hypokalemic Periodic Paralysis (HHPP), marked by acute weakness and hypokalemia. Prompt potassium replacement and hyperthyroidism management are essential to prevent life‐threatening outcomes. This case highlights its presentation in a Nepali male, reinforcing the need for high clinical suspicion.
Tamang A, Sapkota P, Humagain S, Dhakal K, Sachdeva C, Shah D, Lamsal P.   +6 more
europepmc   +2 more sources

Hypokalemic Periodic Paralysis: A Case Report. [PDF]

Cureus
Hypokalaemic periodic paralysis (HPP) is a rare neuromuscular disorder characterized by recurrent episodes of transient muscle weakness associated with hypokalaemia. The condition typically presents in childhood or adolescence. In this case, a 17-year-old male presented with acute-onset limb weakness upon waking. Examination revealed marked truncal and
Wani M, Marchant Z, Nadir U.
europepmc   +3 more sources

When Potassium Takes a Break: A Case Series of 3 Cases on Hypokalemic Periodic Paralysis. [PDF]

Clin Case Rep
ABSTRACT This case series highlights three SHPP cases with varied triggers, managed with potassium supplementation and targeted treatments. Early diagnosis, individualized care, and patient education proved vital in preventing recurrence and complications, emphasizing the need for clinical vigilance and tailored approaches in HPP management.
Kaushal Y, Kaur A, Goyal P, Mateen MA, John J, Tekuru Y, Orfali HA.   +6 more
europepmc   +2 more sources

Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms [PDF]

Endocrinology and Metabolism
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare but potentially fatal complication of thyrotoxicosis, characterized by transient episodes of muscle weakness in the setting of hypokalemia and underlying hyperthyroidism.
Gan Qing, Wan Nur Amalina Zakaria, Fatimah Zahra Mohamad Rom, Wan Nor Fazila Hafizan Wan Nik, Hani Ajrina Zulkeflee, Siti Nadirah Ab Rahim   +5 more
doaj   +2 more sources

Case report: SCN4A p.R1135H gene variant in combination with thyrotoxicosis causing hypokalemic periodic paralysis

Frontiers in Neurology, 2023
Hypokalemic periodic paralysis (HPP) is a heterogeneous group of diseases characterized by intermittent episodes of delayed paralysis of skeletal muscle with episodes of hypokalemia, caused by variants in CACNA1S or SCN4A genes, or secondary to ...
Zhi Zhang, Banghui Xiao
doaj   +3 more sources