Results 1 to 10 of about 1,785 (129)

Hypokalemic Periodic Paralysis in a Young Woman With Mast Cell Activation Syndrome: A Case Report of an Atypical Presentation Associated With an Ultra-Rare CACNA1S Variant. [PDF]

Clin Case Rep
ABSTRACT Hypokalemic periodic paralysis (hKPP) is a rare neuromuscular channelopathy characterized by transient episodes of muscle weakness or paralysis associated with low serum potassium levels. It has been most commonly linked to autosomal dominant mutations in ion channel genes, specifically CACNA1S and SCN4A, which impair skeletal muscle ...
Moradi A, Aboutaleb Y, Noreen S, Sahyouni A, Sharma H, Oyesanmi O, Kahane IM, Lin Y, Toka HR.   +8 more
europepmc   +2 more sources

Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
ABSTRACT Introduction/Aims Hypokalemic periodic paralysis (HypoKPP) is an ion channelopathy causing episodic skeletal muscle weakness triggered by hypokalemia. Reduced inward rectifier K+ (Kir) channel activity contributes to membrane depolarization and paralysis, suggesting that pharmacologic activation of muscle K+ channels may restore excitability ...
Denman K, Rich MM.
europepmc   +2 more sources

Efficacy of a K⁺ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
Pretreatment with an agonist of Kv7 potassium channels (XEN1101) protects the soleus muscle from a loss of force during a 2 mM K+ challenge, in a mouse model of hypokalemic periodic paralysis. ABSTRACT Introduction/Aims Effective management remains lacking for recurrent episodes of acute weakness in hypokalemic periodic paralysis (HypoPP).
Chanchykov V, Iype S, Quinonez M, Wu F, Cannon S.   +4 more
europepmc   +2 more sources

Hypokalemic Periodic Paralysis Associated With a Rare <i>CACNA1S</i> Variant (p.Leu1243Val): Expanding the Mutational Spectrum. [PDF]

Case Rep Genet
Background Hypokalemic periodic paralysis (HypoPP) is a rare skeletal muscle channelopathy, most often caused by mutations in CACNA1S or SCN4A. Most pathogenic CACNA1S mutations affect arginine residues in S4 voltage‐sensor domains, but other variants remain poorly understood.
Nader MA.
europepmc   +2 more sources

A case and literature review of hypokalemic periodic paralysis associated with heavy cola consumption. [PDF]

Front Nutr
This clinical case report involves a 34-year-old male patient with a history of type 2 diabetes and schizophrenia, who took oral olanzapine for a long time and visited the hospital several times because of lower limb fatigue caused by hypokalemia ...
Chen W, Pang Y, Qiu J.
europepmc   +2 more sources

Hyperthyroid Hypokalemic Periodic Paralysis in a Nepali Male; A Case Report. [PDF]

Clin Case Rep
ABSTRACT Hyperthyroid Hypokalemic Periodic Paralysis (HHPP), marked by acute weakness and hypokalemia. Prompt potassium replacement and hyperthyroidism management are essential to prevent life‐threatening outcomes. This case highlights its presentation in a Nepali male, reinforcing the need for high clinical suspicion.
Tamang A, Sapkota P, Humagain S, Dhakal K, Sachdeva C, Shah D, Lamsal P.   +6 more
europepmc   +2 more sources

When Potassium Takes a Break: A Case Series of 3 Cases on Hypokalemic Periodic Paralysis. [PDF]

Clin Case Rep
ABSTRACT This case series highlights three SHPP cases with varied triggers, managed with potassium supplementation and targeted treatments. Early diagnosis, individualized care, and patient education proved vital in preventing recurrence and complications, emphasizing the need for clinical vigilance and tailored approaches in HPP management.
Kaushal Y, Kaur A, Goyal P, Mateen MA, John J, Tekuru Y, Orfali HA.   +6 more
europepmc   +2 more sources

Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms. [PDF]

Endocrinol Metab (Seoul)
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare but potentially fatal complication of thyrotoxicosis, characterized by transient episodes of muscle weakness in the setting of hypokalemia and underlying hyperthyroidism.
Qing G, Zakaria WNA, Rom FZM, Nik WNFHW, Zulkeflee HA, Rahim SNA.   +5 more
europepmc   +2 more sources

Hypokalemic thyrotoxic periodic paralysis in a young Serbian male [PDF]

Vojnosanitetski Pregled, 2020
Introduction. Hypokalemic thyrotoxic paralysis is a very rare form of periodic paralysis in Caucasian population. In this population, a more frequent form is familiar hypokalemic periodic paralysis with the same clinical presentation.
Ristić Petar, Dragović Tamara, Kiković Saša, Ristić Dragana, Zdravković Marija, Hinić Saša, Durmić Tijana, Hajduković Zoran   +7 more
doaj   +1 more source

Hypokalemia with Recurrent Flaccid Paralysis

Indian Journal of Kidney Diseases, 2022
Acute flaccid paralysis is a condition which is attributable to many etiologies. When a patient presents with recurrent acute flaccid paralysis, hypokalemic or hyerkalemic periodic paralysis should be considered especially if similar symptoms are seen in
Poornima Tadkal, Vishwanath Siddini, Kishore Babu, T Chakravarthy   +3 more
doaj   +1 more source