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Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms [PDF]

Endocrinology and Metabolism
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare but potentially fatal complication of thyrotoxicosis, characterized by transient episodes of muscle weakness in the setting of hypokalemia and underlying hyperthyroidism.
Gan Qing, Wan Nur Amalina Zakaria, Fatimah Zahra Mohamad Rom, Wan Nor Fazila Hafizan Wan Nik, Hani Ajrina Zulkeflee, Siti Nadirah Ab Rahim   +5 more
doaj   +3 more sources

Hyperthyroid Hypokalemic Periodic Paralysis in a Nepali Male; A Case Report [PDF]

Clinical Case Reports
Hyperthyroid Hypokalemic Periodic Paralysis (HHPP), marked by acute weakness and hypokalemia. Prompt potassium replacement and hyperthyroidism management are essential to prevent life‐threatening outcomes.
Ashish Tamang, Prakash Sapkota, Sankalpa Humagain, Kemisha Dhakal, Chhavi Sachdeva, Deshant Shah, Prakriti Lamsal   +6 more
doaj   +3 more sources

Hypokalemic Paralysis Is Not Always Periodic: A Case Series

Case Reports in Medicine
Potassium is vital for cellular function, particularly in excitable tissues like nerves and muscles, which rely on potassium gradients to function normally. Hypokalemia can lead to severe issues such as muscle weakness and irregular heart rhythms.
null Mohak Jain, Gaurav Mehta, Ajay Parmar, Minal Shastri, Sahaj Patel, Vidhi Gandhi, Shifa Karatela, Apurva Patel   +7 more
doaj   +3 more sources

Thyrotoxic hypokalemic periodic paralysis and COVID-19 infection [PDF]

Journal of Family Medicine and Primary Care, 2022
Various conditions causing weakness associated with coronavirus disease 2019 (COVID-19) infection have been described, including cerebrovascular diseases, acute myelitis, Guillain-Barré syndrome, myasthenia gravis, critical illness myopathy and ...
Sitanun Chinangkulpiwat, Jutamart Tantiprawan, Jakkrit Amornvit, Patchaya Bunchaya-Anant, Thiti Snabboon   +4 more
doaj   +3 more sources

Thyrotoxic hypokalemic periodic paralysis [PDF]

QJM - Monthly Journal of the Association of Physicians, 2018
Hypokalemia is a serious and life-threatening clinical condition. We present a case of a 45-year-old male, with known hyperthyroidism presenting with profound tremor, irritability, quadriparesis, and labored breathing since morning, on the day of admission. Arterial blood gas analysis showed severe hypokalemia.
Jose Luis HernÁndez
exaly   +5 more sources

Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
ABSTRACT Introduction/Aims Hypokalemic periodic paralysis (HypoKPP) is an ion channelopathy causing episodic skeletal muscle weakness triggered by hypokalemia. Reduced inward rectifier K+ (Kir) channel activity contributes to membrane depolarization and paralysis, suggesting that pharmacologic activation of muscle K+ channels may restore excitability ...
Denman K, Rich MM.
europepmc   +2 more sources

Hypokalemic periodic paralysis: a 3-year follow-up study. [PDF]

J Neurol, 2023
Primary hypokalemic periodic paralysis (HypoPP) is an inherited channelopathy most commonly caused by mutations in CACNA1S. HypoPP can present with different phenotypes: periodic paralysis (PP), permanent muscle weakness (PW), and mixed weakness (MW ...
Holm-Yildiz S, Krag T, Witting N, Pedersen BS, Dysgaard T, Sloth L, Pedersen J, Kjær R, Kannuberg L, Dahlqvist J, de Stricker Borch J, Solheim T, Fornander F, Eisum AS, Vissing J.   +14 more
europepmc   +2 more sources

Unraveling an Uncommon Encounter: Hypokalemic Periodic Paralysis with Brugada Phenocopy Amidst Hypokalemia. [PDF]

Eur J Case Rep Intern Med
Introduction Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the ...
Dankar R, Barakat S, El-Charabaty E, Hashmi SSH, El Sayegh SE.   +4 more
europepmc   +2 more sources

Newly Diagnosed Hypokalemic Periodic Paralysis Triggered by COVID-19. [PDF]

Cureus, 2023
Hypokalemic periodic paralysis (HypoPP) is a rare genetic disorder characterized by low potassium levels and episodic periods of muscle weakness. HypoPP has previously been attributed to numerous viral infections; however, cases related to coronavirus ...
Schulte K, Sheedy M, Feustel K, Scherbak D.   +3 more
europepmc   +2 more sources

Case report: A novel CACNA1S mutation associated with hypokalemic periodic paralysis. [PDF]

Front Neurol, 2023
Background Hypokalemic periodic paralysis (HypoKPP) is a rare neuromuscular genetic disorder causing recurrent episodes of flaccid paralysis. Most cases are associated with CACNA1S mutation, causing defect of calcium channel and subsequent impairment of ...
Nuzhnyi EP, Arestova AS, Rossokhin AV, Protopopova AO, Abramycheva NY, Suponeva NA, Illarioshkin SN.   +6 more
europepmc   +2 more sources