Results 201 to 210 of about 15,210 (229)
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S-adenosyl-L-homocysteine: A non-cytotoxic hypomethylating agent
Experientia, 1994The cytotoxic effect caused by the hypomethylating agent S-adenosyl-L- homocysteine (SAH) was compared with that of two drugs commonly used to induce DNA hypomethylation, 5-azacytidine and 5-aza-2'-deoxycytidine. Two in vitro cytotoxicity tests, the tetrazolium MTT assay and the intracellular lactate dehydrogenase (LDH) activity test, suggest that SAH ...
S F, De Cabo +3 more
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Hypomethylating agents in acute lymphoblastic leukemia: untapped potential?
Leukemia & Lymphoma, 2010Based on pre-clinical data showing patterns of aberrant methylation in myelodysplastic syndromes (MDS) and evidence of cellular differentiation associated with reversal of methylation by decitabine [1–3], MDS became a prime candidate for development of the hypomethylating agents decitabine and 5-azacytidine.
Virginia M, Klimek, Martin S, Tallman
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Use of hypomethylating agents in myelodysplastic syndromes.
Clinical advances in hematology & oncology : H&O, 2007Aberrant DNA methylation is one of the molecular hallmarks of cancer and leukemia. By repressing gene expression, it is considered a functional equivalent to the physical inactivation of tumor suppressor genes by deletions or mutations. To clinically exploit this process, compounds with DNA hypomethylating properties have been evaluated both in the ...
Ehab, Atallah, Guillermo, Garcia-Manero
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Acute Myocarditis Induced by Hypomethylating Agents
Journal of Clinical Oncology, 2011Jean-Emmanuel, Bibault +5 more
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Treatment of Hematologic Malignancies with DNA Hypomethylating Agents
2013The azanucleosides 5-azacytidine (5-aza, Vidaza) and its deoxyribonucleoside analog 5-aza-2′ deoxycytidine (decitabine), while first synthesized and shown to have/possess [besitzen] antileukemic activity in 1964, have only recently been approved for the treatment of myeloid neoplasias.
Michael Daskalakis +3 more
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What’s Next after Hypomethylating Agents Failure in Myeloid Neoplasms? A Rational Approach
Cancers, 2023Hussein Awada +2 more
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