Results 71 to 80 of about 25,285 (271)

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR [PDF]

, 2019
1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB).
Biebermann, Heike, Grüters-Kieslich, Annette, Kalveram, Laura, Kleinau, Gunnar, Rivero-Müller, Adolfo, Scheerer, Patrick, Szymańska, Kamila   +6 more
core   +1 more source

Testicular Function After Immune‐Checkpoint Inhibitors Treatment

Clinical Endocrinology, Volume 103, Issue 5, Page 721-728, November 2025.
ABSTRACT Objective To investigate the effects of immune‐checkpoint inhibitors (ICIs) on spermatogenesis and testicular endocrine function in reproductive‐age men with melanoma. Design Prospective, mixed longitudinal and cross‐sectional cohort study. Patients Twenty‐nine men aged 19–46 years undergoing ICI therapy for melanoma at two Australian centres ...
Andrea Boutros, Amanda Idan, Sue Sleiman, Feyrous Bacha, Ting Zhang, Veena Jayadev, Alexander M. Menzies, Georgina V. Long, David J. Handelsman   +8 more
wiley   +1 more source

Jacobsen Syndrome: A Case Report With Olfactory Bulb Agenesis, Severe Endocrinopathy, and Neurodevelopmental Delay

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Jacobsen syndrome is a rare 11q deletion disorder with multisystem involvement. This case highlights a complex unbalanced 11;15 translocation, olfactory bulb agenesis, extensive white matter abnormalities, and severe endocrinopathies, emphasizing the need for comprehensive genetic and neuroimaging evaluations.
Sajjad Ghanim Al‐Badri, Aditya Duhan, Rania H. Al‐Taie, Muntadher Yousif Hasan Al Gehadi, Ibrahim Khalil   +4 more
wiley   +1 more source

Loperamide-induced hypopituitarism [PDF]

BMJ Case Reports, 2016
Loperamide is the most commonly used antidiarrhoeal medication in the UK. We report a serious and hitherto undocumented adverse effect of chronic use in a 45-year-old man with inflammatory bowel disease. He presented to the endocrine clinic with fatigue and low libido; biochemical assessment revealed hypogonadism and adrenal insufficiency without any ...
Catherine Napier, Catherine Napier, Simon H. S. Pearce, Simon H. S. Pearce, Earn H Gan, Earn H Gan   +5 more
openaire   +4 more sources

Recurrent Symptomatic Hyponatremia Revealing a Late Diagnosis of Sheehan Syndrome and Effectively Treated With Levothyroxine: A Case Report and Brief Review of Literature

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT In women with a history of postpartum hemorrhage presenting with chronic symptoms such as hyponatremia, amenorrhea, weight loss, or cold intolerance, suspect Sheehan's syndrome. Early diagnosis and prompt hormonal replacement therapy are essential for reversing complications and improving quality of life.
Hayatu Awel Abdela, Germen Temam Abdulmalik, Numeri Husein Kimo, Kumel Nur Muktar, Rebi Ali Oumer, Tamirat Godebo Woyimo   +5 more
wiley   +1 more source

Hypoglycemia as a presenting manifestation of Sheehan’s syndrome

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2019
Sheehan’s syndrome is caused by ischemic necrosis of the pituitary gland from massive postpartum uterine bleeding. Despite advances in obstetric care, it is still an important cause of hypopituitarism in developing countries.
Mandeep Singla, Geetika Garg
doaj   +1 more source

Hypopituitarism and cranial nerve involvement mimicking Tolosa-Hunt syndrome as the initially presenting feature of diffuse large B-cell lymphoma: a case report

BMC Endocrine Disorders, 2022
Background Early diagnosis of lymphoma involving the central nervous system is sometimes difficult but emergent to avoid the delay of therapeutic initiation. Pituitary insufficiencies are usually associated with lymphoma in the pituitary gland.
Shohei Kishimoto, Shuhei Morita, Chiaki Kurimoto, Chie Kitahara, Tomoya Tsuji, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Taka-aki Matsuoka   +11 more
doaj   +1 more source

A Case of Ipilimumab Induced Hypophysitis [PDF]

, 2015
Introduction Ipilimumab (Yervoy®) is a human monoclonal antibody that has been shown to significantly improve survival in cases of metastatic melanoma.1 Ipilimumab blocks cytotoxic T-lymphocyte antigen 4 (CTLA-4), a protein receptor on the surface of T ...
Shiffrin, MD, Eric, Ukrainski, MD, Melinda   +1 more
core   +2 more sources

Long‐Term Clinical Outcome and Quality of Life of Children, Adolescents, and Young Adults With Chordoma or Chondrosarcoma Treated With Pencil Beam Scanning Proton Therapy

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Background and Aims To assess clinical outcomes and quality of life (QoL) of children, adolescents, and young adults (C‐AYAs) with chordomas (CH) or chondrosarcomas (CS) after pencil beam scanning proton therapy (pbsPT). Methods A total of 76 C‐AYAs treated between 1999 and 2023 were included. Median age was 16.6 years (1.5–25.4).
Miriam Vazquez, Alexey Cherchik, Claudio de Angelis, Alessia Pica, Gabriele Calaminus, Damien C. Weber   +5 more
wiley   +1 more source

Coverage of education and training of traumatic brain injury-induced growth hormone deficiency in US residency and fellowship programs: a cross-sectional study

BMC Medical Education
Background Hypopituitarism, including growth hormone deficiency (GHD), is a common sequela of traumatic brain injury (TBI). This study explored the coverage of education and training of TBI-induced hypopituitarism in general and GHD in particular, in ...
Javier Cárdenas, Nicky Kelepouris, Radhika Adiga, Kevin C. J. Yuen   +3 more
doaj   +1 more source