Results 71 to 80 of about 22,586 (217)

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Hypoglycemia as a presenting manifestation of Sheehan’s syndrome

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2019
Sheehan’s syndrome is caused by ischemic necrosis of the pituitary gland from massive postpartum uterine bleeding. Despite advances in obstetric care, it is still an important cause of hypopituitarism in developing countries.
Mandeep Singla, Geetika Garg
doaj   +1 more source

Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for x linked hypopituitarism [PDF]

, 2013
Extent: 9 p.Polyalanine expansions in transcription factors have been associated with eight distinct congenital human diseases. It is thought that in each case the polyalanine expansion causes misfolding of the protein that abrogates protein function ...
A Albrecht, A Calado, AN Albrecht, AR La Spada, C Shoubridge, Dale McAninch, E De Baere, E Roessler, EM Burkitt Wright, F Laumonnier, IM Nasrallah, J Wong, James Hughes, JW Innis, K Kitamura, K Rizzoti, KS Alatzoglou, KS Woods, Lynn Rowley, MG Price, MM Laronda, N Brison, Nicholas Rogers, Paul Thomas, QL Ying, Sally Camper, Sandra Piltz, SW Davies, T Wataya, V Dubreuil   +29 more
core   +3 more sources

Sector Classification of Unerupted Maxillary Canines: A Deep Learning‐Based Automated Framework Using Panoramic Radiographs

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objectives To develop a deep learning‐based framework to automate sector classification of unerupted maxillary canines (UMCs), assessing its accuracy and reliability compared to human ones. Material and Methods One thousand five hundred twenty‐eight UMCs from digital panoramic radiographs (PRs) were selected using data from the Dental ...
Marzio Galdi, Davide Cannatà, Flavia Celentano, Luigia Rizzo, Domenico Rossi, Tecla Bocchino, Genoveffa Tortora, Stefano Martina   +7 more
wiley   +1 more source

Hypopituitarism and cranial nerve involvement mimicking Tolosa-Hunt syndrome as the initially presenting feature of diffuse large B-cell lymphoma: a case report

BMC Endocrine Disorders, 2022
Background Early diagnosis of lymphoma involving the central nervous system is sometimes difficult but emergent to avoid the delay of therapeutic initiation. Pituitary insufficiencies are usually associated with lymphoma in the pituitary gland.
Shohei Kishimoto, Shuhei Morita, Chiaki Kurimoto, Chie Kitahara, Tomoya Tsuji, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Taka-aki Matsuoka   +11 more
doaj   +1 more source

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR [PDF]

, 2019
1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB).
Biebermann, Heike, Grüters-Kieslich, Annette, Kalveram, Laura, Kleinau, Gunnar, Rivero-Müller, Adolfo, Scheerer, Patrick, Szymańska, Kamila   +6 more
core   +1 more source

Periodontal and orthodontic management of impacted canines

Periodontology 2000, EarlyView.
Abstract The maxillary and mandibular canines are described by many clinicians as the “cornerstone” of the arch. When in their optimal position, they play a critical role in providing a well‐balanced occlusal scheme that contributes toward functional as well as neuromuscular stability, harmony, esthetics, and dentofacial balance.
Mohammad Qali, Chenshuang Li, Chun‐Hsi Chung, Nipul Tanna   +3 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

A Case of Ipilimumab Induced Hypophysitis [PDF]

, 2015
Introduction Ipilimumab (Yervoy®) is a human monoclonal antibody that has been shown to significantly improve survival in cases of metastatic melanoma.1 Ipilimumab blocks cytotoxic T-lymphocyte antigen 4 (CTLA-4), a protein receptor on the surface of T ...
Shiffrin, MD, Eric, Ukrainski, MD, Melinda   +1 more
core   +2 more sources

Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Shepeng Wei, Xuxu Xu, Jing Bao, Zhenjiang Pan   +3 more
wiley   +1 more source