Results 91 to 100 of about 135,663 (215)

Prevalence and Clinical Characteristics of the LRRK2 p.L1795F Variant in Central Europeans with Early‐Onset and Familial Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) p.L1795F variant was proposed as a genetic risk factor for Parkinson's disease (PD). However, its prevalence, phenotype, and origin remain unknown. Objective The aim was to evaluate the frequency and phenotype of p.L1795F in early‐onset PD (EOPD) and familial PD compared to healthy controls (HC ...
Miriam Ostrozovicova, Gertrud Tamas, Agsha Atputhavadivel, Petr Dusek, Milan Grofik, Vladimir Han, Petr Holly, Robert Jech, Katarina Kalinova, Peter Klivenyi, Norbert Kovacs, Kristina Kulcsarova, Egon Kurca, Alexandra Lackova, Hamin Lee, Patrick Lewis, Veronika Magocova, Maria Marekova, David Murphy, Ai Nagano, Jan Necpal, David Pinter, Miroslava Rabajdova, Evzen Ruzicka, Tereza Serranova, Katarzyna Smilowska, Krisztina Soos, Igor Straka, Tatiana Svorenova, Peter Valkovic, Katerina Zarubova, Zuzana Gdovinova, Henry Houlden, Mie Rizig, Matej Skorvanek, on behalf of the CEGEMOD consortium   +35 more
wiley   +1 more source

Deep Attention Q-Network for Personalized Treatment Recommendation [PDF]

arXiv, 2023
Tailoring treatment for individual patients is crucial yet challenging in order to achieve optimal healthcare outcomes. Recent advances in reinforcement learning offer promising personalized treatment recommendations; however, they rely solely on current patient observations (vital signs, demographics) as the patient's state, which may not accurately ...
arxiv  

Progranulin Mutation Manifesting as Parkinson Disease: A Case Series from the PADUA‐CESNE Cohort

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Mutations in progranulin (GRN) are associated with frontotemporal dementia, although a Parkinson disease (PD) phenotype is uncommon, especially in young patients. Cases We report three subjects from the PADUA‐CESNE cohort, meeting diagnostic criteria for PD, with onset under age 55.
Giulia Bonato, Marta Campagnolo, Aron Emmi, Valentina Misenti, Tommaso Carrer, Carmelo Fogliano, Leonardo Salviati, Miryam Carecchio, Angelo Antonini   +8 more
wiley   +1 more source

Orthostatic hypotension in hereditary transthyretin amyloidosis: epidemiology, diagnosis and management

Clinical Autonomic Research, 2019
Neurogenic orthostatic hypotension is a prominent and disabling manifestation of autonomic dysfunction in patients with hereditary transthyretin (TTR) amyloidosis affecting an estimated 40–60% of patients, and reducing their quality of life.
J. Palma, A. González-Duarte, H. Kaufmann   +2 more
semanticscholar   +1 more source

Role of the Functional Gait Assessment in Validating Item Difficulty Hierarchy and Fall Risk for Idiopathic Normal Pressure Hydrocephalus

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Falls along with gait‐balance disturbances are important symptoms of idiopathic normal pressure hydrocephalus (iNPH). Objectives This study aimed to validate the Functional Gait Assessment (FGA) item‐difficulty hierarchy, determine its optimal fall cutoff value, and identify key items for assessing fall risk in iNPH.
Yasutaka Nikaido, Hideyuki Urakami, Naoya Ishida, Yohei Okada, Yuki Kawami, Takaki Inui, Masahiro Kameda, Yoshinaga Kajimoto, Ryuichi Saura   +8 more
wiley   +1 more source

A unified model for the human response to lipopolysaccharide-induced inflammation [PDF]

arXiv, 2022
This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and anti-inflammatory cytokines (TNF-$\alpha$, IL-6, IL-10), concentrations of corticotropin-releasing hormone (CRH ...
arxiv  

Investigating Dopamine Replacement–Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan, Christopher B. Morrow, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone   +4 more
wiley   +1 more source

Frequency Distribution of Orthostatic Hypotension, Nocturnal Hypertension, and Postprandial Hypotension in Patients with Parkinson's Disease: A Case- Control Study

مجله دانشکده پزشکی اصفهان, 2012
Background: Orthostatic hypotension is a common autonomic dysfunction in Parkinson's disease. Major hypotheses proposed in the etiology of orthostatic hypotension include sympathetic denervation and treatment with dopaminergic drugs.
Ahmad Chitsaz, Mohammad Saadatnia, Maliheh Khalili Bandali   +2 more
doaj  

Predicting Blood Pressure Response to Fluid Bolus Therapy Using Attention-Based Neural Networks for Clinical Interpretability [PDF]

arXiv, 2018
Determining whether hypotensive patients in intensive care units (ICUs) should receive fluid bolus therapy (FBT) has been an extremely challenging task for intensive care physicians as the corresponding increase in blood pressure has been hard to predict. Our study utilized regression models and attention-based recurrent neural network (RNN) algorithms
arxiv  

The Prevalence of Orthostatic Hypotension: A Systematic Review and Meta-Analysis

The journals of gerontology. Series A, Biological sciences and medical sciences, 2018
Background Orthostatic hypotension (OH) is associated with increased risk of falls, cognitive impairment and death, as well as a reduced quality of life. Although it is presumed to be common in older people, estimates of its prevalence vary widely.
N. Saedon, Maw Pin Tan, J. Frith
semanticscholar   +1 more source