Results 191 to 200 of about 159,287 (258)

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, Volume 14, Issue 12, December 2025.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Discriminating between proposed Brain-First and Body-First Parkinson's disease using conventional and radiomics-enhanced dopamine transporter SPECT image analysis. [PDF]

NPJ Parkinsons Dis
Palermo G, Aghakhanyan G, Bellini G, Giannoni S, Vadi G, Francischello R, Nonne G, Tedeschi MG, Morganti R, Frosini D, Pavese N, Volterrani D, Ceravolo R.   +12 more
europepmc   +1 more source

The role of 24‐hour wearable sensors in early evaluation of adolescent orthostatic dysregulation

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim We investigated orthostatic dysregulation using wearable sensors capable of monitoring electrocardiograms (ECGs) and motion via accelerometers. Methods Study 1: Thirty‐three healthy students participated in the study. Wearable sensors recorded continuous 24‐h ECGs, and a triaxial accelerometer was fixed to the participants' waist for three
Yasuki Ono, Hiromasa Tsugiguchi, Kouichi Sagawa, Kuniko Sato, Tetsu Hirosawa, Daiki Soma, Akinori Hara, Keita Suzuki, Sakae Miyagi, Aya Ogawa, Masaharu Nakamura, Chie Takazawa, Hiroyuki Nakamura, Mototsugu Ogura, Mitsuru Kikuchi   +14 more
wiley   +1 more source

Gonadal Function and Reproductive Health Challenges in Triple a Syndrome: A Narrative Review. [PDF]

Medicina (Kaunas)
Gheorghe-Milea A, Georgescu CE.
europepmc   +1 more source

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Inhibition of vasocontraction accounts for side effects in treating voiding symptoms in benign prostatic hyperplasia (BPH). We examined the vasoactivity of compounds previously showing inhibition of prostate smooth muscle contraction. Contractions of porcine renal interlobar and coronary arteries were induced by agonists or electric field ...
Guangyang Liu, Sheng Hu, Alexander Tamalunas, Oluwafemi Kale, Yajie Xu, Christian G. Stief, Martin Hennenberg   +6 more
wiley   +1 more source

Autonomic Dysfunction Following Surgical Resection of Cervicomedullary Hemangioblastoma: A Case Report and Literature Review. [PDF]

Cureus
Alshahrani N, Alqurashi M, Alzidani T, Hafiz BE, Basurrah AA, Aref M.   +5 more
europepmc   +1 more source

Peripheral Neuropathy Associated With Proteasome Inhibitors and Immunomodulatory Drugs: A Pharmacovigilance Disproportionality Analysis Using VigiBase

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Immunomodulatory drugs (IMIDs) and proteasome inhibitors (PIs) are part of the frontline treatment landscape for multiple myeloma (MM). Despite their effectiveness, these drugs are associated with adverse effects, particularly clinically significant drug‐induced peripheral neuropathy.
Letícia Penna Braga, Cristiane Aparecida Menezes de Pádua, Iwyson Henrique F. da Costa, Paula Lana de Miranda Drummond, Pedro Henrique Carvalho de Souza, Laura Beatriz Fonseca, Marina Alacoque Rodrigues, Jéssica Soares Malta, Adriano Max Moreira Reis   +8 more
wiley   +1 more source

Comparison of two peripheral regional analgesic techniques for primary elective total hip arthroplasty: a randomised clinical trial

Anaesthesia, Volume 80, Issue 12, Page 1501-1509, December 2025.
Summary Introduction Several regional anaesthesia techniques have been used in the peri‐operative pain management of patients who undergo primary elective total hip arthroplasty. The erector spinae plane, pericapsular nerve group and lateral femoral cutaneous nerve blocks offer motor‐sparing analgesia of the hip region but target different areas.
Francesca Buffoli, Claudia Bonetti, Camilla Pugno, Andrea Minini, Silvia Bettinelli, Arianna Mancini, Alessandro Colombi, Alberto Benigni, Edward R. Mariano, Luca F. Lorini, Dario Bugada   +10 more
wiley   +1 more source

Case-control study of autonomic symptoms in the setting of Long COVID with tilt table testing. [PDF]

PLoS One
Durstenfeld MS, Mataraarachchi N, Peluso MJ, Levkova-Clark M, Schaffer V, Fehrman EA, Anderson G, Flores D, Henrich TJ, Long CS, Deeks SG, Hsue PY.   +11 more
europepmc   +1 more source

Cerebellar and Brainstem White Matter Geometric Alterations in Multiple System Atrophy: A DFA‐Based Biomarker for Disease Staging

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
Director field analysis (DFA) uncovers spatially divergent white matter degeneration in MSA‐C: cerebellar fiber simplification (decreased splay/bend) reflects Wallerian degeneration, while brainstem twist reduction (decreased twist) tracks disease progression (AUC = 0.95).
Hua Zhu, Shuxiang Zhu, Meixin Zhao, Ziyan Zhu, Yuxuan Shao, Xinxi Lu, Tao Liu, Haogang Zhu, Ni Shu, Hua Lin, Jian Cheng   +10 more
wiley   +1 more source