Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]
, 2016 BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois +10 more
core +3 more sources
Periosteal nociceptors induced hypotension and bradycardia under spinal anesthesia -A report of two cases- [PDF]
Korean Journal of Anesthesiology, 2011 The sudden hemodynamic disturbance in the perioperative period can occur because of various surgical and anesthetic reasons but hemodynamic collapse due to noxious stimulus of periosteum stripping has not been described.
Rakesh Garg +2 more
doaj +1 more source
Biology, 2021 Spinal anesthesia is generally accepted as an effective and safe practice. Three rare incidents of postoperative cerebral infarction after surgery under spinal anesthesia prompted us to assess whether spinal bupivacaine may compromise carotid or cerebral
Yan-Yuen Poon +4 more
doaj +1 more source
Male gender predisposes to development of endotoxic shock in the rat [PDF]
, 2000 Objective: After intravenous (i.v.) injection of lipopolysaccharide (LPS) macrophages release nitric oxide (NO) due to the expression of the inducible NO synthase (iNOS).
Baylis, C. +7 more
core +1 more source
Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe? [PDF]
, 2017 Aims: Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes.
Bourge, Robert C +17 more
core +5 more sources
Is there NO treatment for severe sepsis? [PDF]
, 2008 Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core +2 more sources
Hypotensive Resuscitation [PDF]
Current Anesthesiology Reports, 2014 Hypotensive resuscitation is a component of damage control resuscitation, the evolving approach to resuscitation in severely injured trauma patients. Resuscitation strategies used in treating severely injured trauma patients have changed dramatically over the last 20 years.
Jeremy B, Smith +2 more
openaire +2 more sources
Effect of interscalene brachial plexus block on heart rate variability [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundInterscalene brachial plexus block (ISB) may be followed by cardiovascular instability. Until date, there is no clear picture available about the underlying mechanisms of ISB.
Marina Simeoforidou +6 more
doaj +1 more source
Anaphylaxis induced by sugammadex and sugammadex-rocuronium complex -a case report- [PDF]
Korean Journal of Anesthesiology, 2020 Background In sugammadex-induced anaphylaxis, sugammadex and/or sugammadex-rocuronium complex have possible allergenic epitope. Case We report a case of sugammadex-induced anaphylaxis during general anesthesia in a 60-year-old male undergoing orthopedic ...
Shu Chung Choi +3 more
doaj +1 more source
A case of bilateral sequential optic neuropathy in a young adult post hemodialysis
Kerala Journal of Ophthalmology, 2021 Ischemic optic neuropathy is a very rare but well-known complication following hemodialysis in patients with chronic kidney disease, It can be potentially blinding when involving both optic nerves and there is no effective established treatment available
Harsha Sameer Pagad +2 more
doaj +1 more source