Results 101 to 110 of about 153,410 (301)

Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.

PLoS ONE, 2020
Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A1 receptors (A1AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injection
Haley S Province, Cuiying Xiao, Allison S Mogul, Ankita Sahoo, Kenneth A Jacobson, Ramón A Piñol, Oksana Gavrilova, Marc L Reitman   +7 more
doaj   +1 more source

Accidental hypothermia–an update

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2016
BackgroundThis paper provides an up-to-date review of the management and outcome of accidental hypothermia patients with and without cardiac arrest.MethodsThe authors reviewed the relevant literature in their specialist field.
P. Paal, L. Gordon, G. Strapazzon, Monika Brodmann Maeder, G. Putzer, B. Walpoth, M. Wanscher, Doug Brown, M. Holzer, G. Broessner, H. Brugger   +10 more
semanticscholar   +1 more source

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

The Anatomical Record, EarlyView.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek, Feyzullah Beyaz, Mustafa Öztop, Harun Karaca, Ahmet Cabir, Begüm Fatma Kiryar   +5 more
wiley   +1 more source

Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest.

PLoS ONE, 2019
Therapeutic hypothermia initiated during cardiopulmonary resuscitation (CPR) in pre-clinical studies appears to be highly protective against sudden cardiac arrest injury.
Jing Li, Xiangdong Zhu, Huashan Wang, Chunpei Lee, Sy-Jou Chen, Yuanyu Qian, Mei Han, Ryan Bunney, David G Beiser, Terry L Vanden Hoek   +9 more
doaj   +1 more source

Understanding thermoregulatory transitions during haemorrhage by piecewise regression [PDF]

arXiv, 2010
Transition points are common in physiological processes. However the transition between normothermia and hypothermia during haemorrhagic shock has rarely been systematically quantified from intensive time series data. We estimated the critical transition point (CTP) and provided confidence intervals for core body temperature response to acute severe ...
arxiv  

Intraoperative hypothermia and its clinical outcomes in patients undergoing general anesthesia: National study in China

PLoS ONE, 2017
Background/Objective Inadvertent intraoperative hypothermia (core temperature 2 h) (OR = 2.60, 95% CI 2.09–3.24). Conclusions The incidence of intraoperative hypothermia in China is high, and the rate of active warming of patients during operation is low.
Jie Yi, Y. Lei, Shiyuan Xu, Yongyu Si, Shiyang Li, Z. Xia, Yi-sa Shi, X. Gu, Jianshe Yu, Guohai Xu, E. Gu, Yonghao Yu, Yan-qiang Chen, H. Jia, Yinglin Wang, Xiuli Wang, Xiaoqing Chai, Xiaoju Jin, Junping Chen, Meiying Xu, Jun-yu Xiong, Guonian Wang, K. Lu, Wenli Yu, Weifu Lei, Zaisheng Qin, J. Xiang, Longyun Li, Ziyong Xiang, S. Pan, L. Zhan, Kai Qiu, Min Yao, Yuguang Huang   +33 more
semanticscholar   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Novel 4,5‐Dihydrothiazole‐phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

ChemMedChem, Accepted Article.
We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła-Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino   +18 more
wiley   +1 more source

TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

Acta Physiologica, 2018
Thermoregulatory side effects hinder the development of transient receptor potential vanilloid‐1 (TRPV1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well‐studied effect, some cause hypothermia.
A. Garami, A. Garami, Eszter Pákai, Eszter Pákai, H. McDonald, R. Reilly, A. Gomtsyan, J. Corrigan, E. Pintér, D. Zhu, S. Lehto, N. Gavva, P. Kym, A. A. Romanovsky   +13 more
semanticscholar   +1 more source

A contemporary simple risk score for prediction of severe acute kidney injury after heart transplantation

ESC Heart Failure, Volume 12, Issue 2, Page 1166-1175, April 2025.
A contemporary simple risk score for prediction of severe AKI after HT. Abstract Background The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.
Shuangshuang Zhu, Weihua Qiao, Yixuan Wang, Ying Zhou, Yin Xu, Shijie Wang, Tian Xia, Guohua Wang, Si Chen, Jiawei Shi, Nianguo Dong   +10 more
wiley   +1 more source