Results 261 to 270 of about 152,307 (344)

Infantile Cerebellar‐Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model

Clinical Genetics, EarlyView.
Our Translational Loop integrates patient genetic data with Drosophila models to study disease mechanisms. We identified ACO2 variants in a patient linked to ICRD and show that our animal model mirrors key aspects of the disease. These insights help pinpoint therapeutic targets, advancing research toward treatments for rare genetic disorders.
Edgar Buhl, Suchika Garg, Marie Monaghan, Amy Preston, Marcus Likeman, Julianne Dare, Julie Evans, Lucie S. Taylor, Ian Berry, Kathryn Urankar, Paul G. D. Spry, Cathy Williams, Robert W. Taylor, Charlotte L. Alston, James J. L. Hodge, Anirban Majumdar   +15 more
wiley   +1 more source

Warming with a composite warming strategy reduces intraoperative hypothermia in patients undergoing open hepatectomy for liver cancer: A randomized controlled study. [PDF]

Medicine (Baltimore)
Yi N, Wang Z, Cui R.
europepmc   +1 more source

Mind the Gap! Core-Peripheral Temperature Gradient and Its Relationship to Mortality in Major Burns. [PDF]

Eur Burn J
Keohane N, Driver J, Mullhi R, Chipp E, Torlinska B, Torlinski T.   +5 more
europepmc   +1 more source

The risk of epilepsy after neonatal seizures

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16288 Abstract Aim To estimate the cumulative risk of epilepsy after neonatal seizures and identify subpopulations at increased risk. Method This was a nationwide register‐based cohort study including all children born in Denmark between 1997 and 2018.
Jeanette Tinggaard, Signe V. Pedersen, Mads L. Larsen, Andreas K. Jensen, Gorm Greisen, Bo M. Hansen, Christina E. Hoei‐Hansen   +6 more
wiley   +1 more source

Potential Biomarkers of Fatal Hypothermia Revealed by UHPLC-MS Metabolomics in Mice. [PDF]

Metabolites
Cao XZ, Wu ZW, Ma XY, Deng WL, Chen DH, Liu JL, Li JH, Wang H, Pei BQ, Zhao D, Wang Q.   +10 more
europepmc   +1 more source

A narrative review of metformin in pregnancy: Navigating benefit and uncertainty

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metformin is well‐established as a treatment for type 2 diabetes in non‐pregnant individuals. The low cost, acceptability and broad tolerability of metformin have also made it an attractive option for research into the treatment of other conditions associated with insulin resistance.
Robert P. McEvoy, Christine Newman, Aoife M. Egan, Fidelma P. Dunne   +3 more
wiley   +1 more source

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice. [PDF]

Elife
Ferhat L, Soussi R, Masse M, Kyriatzis G, Girard S, Gassiot F, Gaudin N, Laurencin M, Bernard A, Bôle A, Ferracci G, Smirnova M, Roman F, Dive V, Cisternino S, Temsamani J, David M, Lécorché P, Jacquot G, Khrestchatisky M.   +19 more
europepmc   +1 more source

Unique features of seizure‐induced cardiorespiratory failure in SSKcnj16−/− rats: Implications for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure‐induced disruption of vital physiological systems. The objective of this study was to characterize seizure‐induced physiological dysfunction leading to death in SSKcnj16−/− rats and ...
Melissa Eilbes, Alexander Gallo, Wasif A. Osmani, Paloma Bittencourt‐Silva, Anna D. Manis, Matthew R. Hodges   +5 more
wiley   +1 more source

Implementing Guidelines for hypothermia prevention with Local adaptation to keep periOperative patients Warm (GLOW): protocol of a stepped-wedge cluster randomised hybrid type II effectiveness-implementation study. [PDF]

BMJ Open
Munday J, Duff J, Wood FM, Sturgess D, Keogh S, Ralph N, White NM, Carter H, Graham ID.   +8 more
europepmc   +1 more source

MULTICHANNEL ELECTROENCEPHALOGRAPHY IN HYPOTHERMIA AND CIRCULATORY OCCLUSION

, 1960
W. CURTIS PEARCY, robert virtue
openalex   +1 more source