Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A Five-Region Hypothesis Test for Exposure-Disease Associations. [PDF]
Sci Rep, 2017 Shih HY, Lee WC.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Experimental Activity on High Temperature PEM Fuel Cells
, 2013 Energy systems based on fuel cells technology have received increasing attention because, by providing both useful electricity and heat with high efficiency, even at partial loads, can have a strategic role in reduction of greenhouse gas emissions ...
Perna, A. +5 more
core
Resemblance profiles as clustering decision criteria: Estimating statistical power, error, and correspondence for a hypothesis test for multivariate structure. [PDF]
Ecol Evol, 2017 Kilborn JP +3 more
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The efficient market hypothesis re-visited: new evidence from 100 US firms [PDF]
In this paper, we test the efficient market hypothesis for 100 US firms listed on the New York Stock Exchange. To test the unit root null hypothesis, we develop a generalized autoregressive heteroskedasticity (GARCH) model that not only caters for the ...
Ruipeng Liu, Paresh Kumar Narayan
core
Cognate reflex prediction as hypothesis test for a genealogical relation between the Panoan and Takanan language families. [PDF]
Sci RepBlum F +3 more
europepmc +1 more source
A default Bayesian hypothesis test for correlations and partial correlations. [PDF]
Psychon Bull Rev, 2012 Wetzels R, Wagenmakers EJ.
europepmc +1 more source