Results 211 to 220 of about 10,248,752 (301)

Automated pharmacophore hypothesis generator for SILCS-Pharm: ph4gen. [PDF]

J Comput Aided Mol Des
Nordquist EB, MacKerell AD.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Falsification and experimental psychology: examples from face perception. [PDF]

Integr Psychol Behav Sci
Rakover SS.
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

A Retrospective Radiographic Study of Metacarpal and Phalangeal Length Proportions: Testing the Golden Ratio, Fibonacci, and Lucas Models. [PDF]

Cureus
Singh S, Wong KY, Zafiropoulos G.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

<i>p</i>-Values Are Not Evidence: Navigating the Gap Across Modes of Inference. [PDF]

Ecol Evol
Arno HE, Blackmore RJ, Crowley SE, Evon SMR, Fleming IA, Fountain CT, Hamisch S, Monk EM, Robitaille AL, Schneider DC.   +9 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

ManyBabies 3: A Multi-Lab Study of Infant Algebraic Rule Learning. [PDF]

Dev Sci
Visser I, Geambasu A, Kachergis G, Oliveira CM, Rocha-Hidalgo J, Zettersten M, Ahamat T, Alessandroni N, Althaus N, Arunachalam S, Aussems S, Axelsson EL, Aydin Z, Baumgartner HA, Bergmann C, Bettoni R, Black AK, Bulf H, Byers-Heinlein K, Capparini C, Carroll L, Carstensen A, Cebulla R, Chen X, Chládková K, Colavolpe B, Constantine RR, Cortes EE, Doyle FL, Exner A, Forbes SH, Franchin L, Geraci A, Gervain J, Gonzalez-Gomez N, Hagelund S, Hannon EE, Havron N, Jaffe-Dax S, Johnson SP, Jędryczka W, Kartushina N, Struhl MK, Koleini A, Kona A, Kong SP, Kosie JE, Kuc̆erová M, Cook K, Leslie JW, Lew-Williams C, Li SWY, Livne R, Marklund E, Mayor J, Misiak M, Moreau D, Mueller JL, Muhinyi A, Quinn AA, Raijmakers MEJ, Rosslund A, Schwarz IC, Shinskey JL, Shukla M, Sirois S, Sorokowski P, Sowan B, Tauzin T, Tsui ASM, Turconi M, Urizar RC, Wagner L, Wermelinger S, Westermann G, Weyers I, Yuan LSB, Zaharieva MS, Zamuner TS, Zapiór B, Zasso S, Zhou JG, Soderstrom M, Levelt CC.   +83 more
europepmc   +1 more source