Results 241 to 250 of about 10,248,752 (301)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

The Effects of Exergames on Fundamental Movement Skills in Childhood: A Systematic Review and Meta-analysis. [PDF]

Sports Med Open
O'Brien O, Kendrick C, Ives B, Yap MH, Henry J.   +4 more
europepmc   +1 more source

Rethinking gonadotropin releasing hormone agonist suppression test: why it should be a gonadotropin releasing hormone antagonist suppression test. [PDF]

J Endocr Soc
Munshi R, Coutu Nadeau LP, Dahan MH.
europepmc   +1 more source

Explainable machine learning framework with Granger-based temporal predictive validation for monitoring fiscal risk in national health insurance expenditure. [PDF]

PLoS One
Lee G.
europepmc   +1 more source

A Frequentist Approach Using Weighted Estimating Equations for Survival Analysis of Randomized Controlled Trial With External Control Arm. [PDF]

Biom J
Sawamoto R, Oba K, Matsuyama Y.
europepmc   +1 more source

Reducing English Speaking Anxiety and Building Communicative Competence Through Multimodal Immersive Virtual Environments: A Mixed-Methods Study of the Serial Mediation of Presence and Self-Efficacy Among Chinese University EFL Learners. [PDF]

Psychol Res Behav Manag
Gao W, Zou C.
europepmc   +1 more source