Results 191 to 200 of about 16,679,614 (365)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Estimation of parameters and hypothesis testing of multivariate spatial autoregressive model. [PDF]

MethodsX
Sutikno, Purhadi, Fachrunisah, Cahyoko FD.   +3 more
europepmc   +1 more source

Iterative hypothesis testing in HIV vaccine research: moving towards success. [PDF]

J Int AIDS Soc, 2023
Anklesaria P, Russell ND.
europepmc   +1 more source

On Hypothesis Testing in Distributed Sensor Networks. [PDF]

, 1987
Z. Chair, Pramod K. Varshney
openalex   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Detecting implicit biases of large language models with Bayesian hypothesis testing. [PDF]

Sci Rep
Si S, Jiang X, Su Q, Carin L.
europepmc   +1 more source

Simultaneous hypothesis testing for multiple competing risks in comparative clinical trials. [PDF]

Stat Med, 2023
Wen J, Wang MC, Hu C.
europepmc   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Hypothesis testing for detecting outlier evaluators. [PDF]

Int J Biostat
Xu L, Zucker DM, Wang M.
europepmc   +1 more source

Methods for large-scale single mediator hypothesis testing: Possible choices and comparisons. [PDF]

Genet Epidemiol, 2023
Du J, Zhou X, Clark-Boucher D, Hao W, Liu Y, Smith JA, Mukherjee B.   +6 more
europepmc   +1 more source