Results 201 to 210 of about 2,690,705 (301)

Iterative hypothesis testing in HIV vaccine research: moving towards success. [PDF]

J Int AIDS Soc, 2023
Anklesaria P, Russell ND.
europepmc   +1 more source

A POWERFUL TEST OF THE AUTOREGRESSIVE UNIT ROOT HYPOTHESIS BASED ON A TUNING PARAMETER FREE STATISTIC

, 2009
Morten Ørregaard Nielsen
openalex   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Statistical Hypothesis Testing with SAS and R

Journal of Statistical Software, 2015
Abdolvahab Khademi
doaj   +1 more source

Coconut: covariate-assisted composite null hypothesis testing with applications to replicability analysis of high-throughput experimental data. [PDF]

BMC Bioinformatics
Li Y, Li Y, Ma H, Yue Z, Zhang X.
europepmc   +1 more source

Simultaneous hypothesis testing for multiple competing risks in comparative clinical trials. [PDF]

Stat Med, 2023
Wen J, Wang MC, Hu C.
europepmc   +1 more source

Surface runoff features on Mars: Testing the carbon dioxide formation hypothesis [PDF]

, 2002
Sarah T. Stewart, F. Nimmo
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evaluating the Accuracy and Explanatory Quality of Large Language Models ChatGPT, Claude, DeepSeek, Gemini, Grok, and Le Chat in Statistical Test Selection for Hypothesis Testing Decisions. [PDF]

Cureus
Shukla M, Pandey D, Kaur S, Agarwal M, Goyal A, Sharma H.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source