ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Does categorizing scale scores with cutoff points affect hypothesis-testing results? [PDF]
Sayili U +8 more
europepmc +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
A Survey on Error Exponents in Distributed Hypothesis Testing: Connections with Information Theory, Interpretations, and Applications. [PDF]
Espinosa S, Silva JF, Céspedes S.
europepmc +1 more source
Using Bayesian Hypothesis-testing to Reanalyze Randomized Controlled Trials: Does it Always Tell the Truth, the Whole Truth and Nothing but the Truth? [PDF]
Ho KM, Lee A.
europepmc +1 more source
Comparing researchers' degree of dichotomous thinking using frequentist versus Bayesian null hypothesis testing. [PDF]
Muradchanian J +4 more
europepmc +1 more source
RegionScan: a comprehensive R package for region-level genome-wide association testing with integration and visualization of multiple-variant and single-variant hypothesis testing. [PDF]
Brossard M +6 more
europepmc +1 more source
Enhancing system safety in critical architectures: Augmented hypothesis testing with early design knowledge. [PDF]
M Rashid FK.
europepmc +1 more source

