Results 241 to 250 of about 439,676 (282)

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Longitudinal Diaphragm Ultrasound Assessment Across Respiratory Support Modalities in Critically Ill Infants and Children: A Prospective Cohort Study. [PDF]

Children (Basel)
Boydag Guvenc K, Guney Sahin E, Yılmaz IA, Varol F, Durak C.   +4 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Multimodal Assessment of Breast Cancer-Related Lymphedema Using Bioimpedance Analysis, Ultrasound Tissue Thickness, and Shear Wave Elastography. [PDF]

Diagnostics (Basel)
Bang MH, Song HL, Jo G, Do HK.
europepmc   +1 more source

Toward FIAP^®-Digital: an interpretable multimodal AI architecture for translational stratification and precision care in Autism. [PDF]

Front Neuroinform
Fuamba Y.
europepmc   +1 more source

Temporal predictions shape somatosensory perception. [PDF]

Nat Commun
Strube A, Büchel C.
europepmc   +1 more source

Effects of simulated and real opioid withdrawal on delay discounting for opioids and money in people who use fentanyl daily. [PDF]

Exp Clin Psychopharmacol
Shellenberg TP, Baidwan T, Johansen AN, Strickland JC, Martinez S, Regnier SD, Wesley MJ, Babalonis SL, Stoops WW, Lile JA.   +9 more
europepmc   +1 more source

Dietary Behavior, Physical Activity, and 24-Hour Rhythm Coherence: A Digital Phenotyping Perspective on Vascular and Glycemic Health. [PDF]

Nutrients
Sun G, Jia X, Zhang H, Yu R, Rong S, Liu Y, Qi Y, Chen S.   +7 more
europepmc   +1 more source